2. Anti-infection
  3. Beta-lactamase Bacterial
  4. Metallo β-lactamase ligand 1

Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A.

For research use only. We do not sell to patients.

Metallo β-lactamase ligand 1 Chemical Structure

Metallo β-lactamase ligand 1 Chemical Structure

CAS No. : 1087784-71-1

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5 mg USD 46 In-stock
10 mg USD 74 In-stock
25 mg USD 148 In-stock
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Based on 1 publication(s) in Google Scholar

Metallo β-lactamase ligand 1 Related Antibodies

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Metallo-β-lactamase

  • Biological Activity

  • Purity & Documentation

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Description

Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A[1].

In Vitro

One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent[1].
The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Metallo β-lactamase ligand 1 Related Antibodies
In Vivo

After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

219.22

Formula

C7H9NO5S
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

CC1=C(S(=O)(N)=O)C(C(O)=O)=C(C)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1140.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5616 mL 22.8081 mL 45.6163 mL
5 mM 0.9123 mL 4.5616 mL 9.1233 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5616 mL 22.8081 mL 45.6163 mL 114.0407 mL
5 mM 0.9123 mL 4.5616 mL 9.1233 mL 22.8081 mL
10 mM 0.4562 mL 2.2808 mL 4.5616 mL 11.4041 mL
15 mM 0.3041 mL 1.5205 mL 3.0411 mL 7.6027 mL
20 mM 0.2281 mL 1.1404 mL 2.2808 mL 5.7020 mL
25 mM 0.1825 mL 0.9123 mL 1.8247 mL 4.5616 mL
30 mM 0.1521 mL 0.7603 mL 1.5205 mL 3.8014 mL
40 mM 0.1140 mL 0.5702 mL 1.1404 mL 2.8510 mL
50 mM 0.0912 mL 0.4562 mL 0.9123 mL 2.2808 mL
60 mM 0.0760 mL 0.3801 mL 0.7603 mL 1.9007 mL
80 mM 0.0570 mL 0.2851 mL 0.5702 mL 1.4255 mL
100 mM 0.0456 mL 0.2281 mL 0.4562 mL 1.1404 mL
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Metallo β-lactamase ligand 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metallo β-lactamase ligand 11087784-71-1Beta-lactamaseBacterialβ-lactamaseantibioticsantibacterialsulfamoylcarboxylInhibitorinhibitorinhibit

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