Methacrylic anhydride

Name: Methacrylic anhydride
Brand: MedChemExpress
SKU: HY-W017330
Rating: 4.5 (1 reviews)

Cat. No.: HY-W017330 Purity: 97.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Methacrylic anhydride is a typical polymerizable 1,6-diolefin. Methacrylic anhydride can form a soluble csyclopolymer by free-radical initiation. Methacrylic anhydride can spontaneously polymerize through the vinyl group and justifies the use of 2-6-di-tert-butyl4-methylphenol as an inhibitor.

For research use only. We do not sell to patients.

Methacrylic anhydride Chemical Structure

CAS No. : 760-93-0

Size	Price	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Liquid
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
1 g	USD 40	In-stock	Estimated Time of Arrival: December 31
5 g	USD 45	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Methacrylic anhydride

•Int J Mol Sci. 2023 Aug 25, 24(17), 13210.

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

154.17

Formula

C₈H₁₀O₃

CAS No.

760-93-0

Appearance

Liquid (Density: 1.035 g/cm³)

Color

Colorless to light yellow

SMILES

CC(C(OC(C(C)=C)=O)=O)=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (648.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.4863 mL	32.4317 mL	64.8635 mL
5 mM	1.2973 mL	6.4863 mL	12.9727 mL
10 mM	0.6486 mL	3.2432 mL	6.4863 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.27%

Select Batch:

Data Sheet (271 KB) SDS (617 KB)

COA (246 KB) HNMR (109 KB) GC (195 KB)

Handling Instructions (2659 KB)

References

[1]. Jesse C. H. Hwa, et al. Copolymerization of methacrylic anhydride with vinyl monomers. Journal of Polymer Science. November 1961, 55(161):197-213.

[2]. F. Becquart, et al. Functionalization of a poly(vinyl alcohol) in the solid state with a swelling agent by methacrylic anhydride. Polymer Chemistry. 1 April 2004, 42(7):1618-1629.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.4863 mL	32.4317 mL	64.8635 mL	162.1587 mL
	5 mM	1.2973 mL	6.4863 mL	12.9727 mL	32.4317 mL
	10 mM	0.6486 mL	3.2432 mL	6.4863 mL	16.2159 mL
	15 mM	0.4324 mL	2.1621 mL	4.3242 mL	10.8106 mL
	20 mM	0.3243 mL	1.6216 mL	3.2432 mL	8.1079 mL
	25 mM	0.2595 mL	1.2973 mL	2.5945 mL	6.4863 mL
	30 mM	0.2162 mL	1.0811 mL	2.1621 mL	5.4053 mL
	40 mM	0.1622 mL	0.8108 mL	1.6216 mL	4.0540 mL
	50 mM	0.1297 mL	0.6486 mL	1.2973 mL	3.2432 mL
	60 mM	0.1081 mL	0.5405 mL	1.0811 mL	2.7026 mL
	80 mM	0.0811 mL	0.4054 mL	0.8108 mL	2.0270 mL
	100 mM	0.0649 mL	0.3243 mL	0.6486 mL	1.6216 mL