2. Cell Cycle/DNA Damage
  3. Antifolate DNA/RNA Synthesis
  4. Methotrexate α-tert-butyl ester

Methotrexate α-tert-butyl ester 

Cat. No.: HY-133887 Purity: ≥96.0%
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Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent.

For research use only. We do not sell to patients.

Methotrexate α-tert-butyl ester Chemical Structure

Methotrexate α-tert-butyl ester Chemical Structure

CAS No. : 79640-70-3

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Based on 1 publication(s) in Google Scholar

Methotrexate α-tert-butyl ester Related Antibodies

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Description

Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent[1][2][3][4].

In Vitro

OtBu-MTX-PVG is less HT1080 than MTX-PVG against HT1080 cells. It shows that protection of the α-carboxyl group of MTX results in reduced in vitro activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methotrexate α-tert-butyl ester Related Antibodies
In Vivo

Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice[1].
The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells)[1]
Dosage: 30 mg/kg
Administration: Once per week for 2 weeks
Result: Showed a significant (63%) reduction in tumor size on day 12.
Molecular Weight

510.55

Formula

C24H30N8O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CC[C@H](NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1)=O)C(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Methotrexate α-tert-butyl ester Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methotrexate α-tert-butyl ester79640-70-3AntifolateDNA/RNA SynthesisOtButumorgrowthHT1080cellscirculatoryhalf-lifeInhibitorinhibitorinhibit

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