2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Autophagy Anti-infection
  3. Glucocorticoid Receptor Autophagy SARS-CoV
  4. Methylprednisolone-d7

Methylprednisolone-d7  (Synonyms: U 7532-d7)

Cat. No.: HY-B0260S3 Purity: 99.73%
SDS COA Handling Instructions

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Methylprednisolone-d7 is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

For research use only. We do not sell to patients.

Methylprednisolone-d<sub>7</sub> Chemical Structure

Methylprednisolone-d7 Chemical Structure

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1 mg USD 2350 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Methylprednisolone-d7:

Methylprednisolone-d7 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Methylprednisolone-d7 is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methylprednisolone-d7 Related Antibodies
Molecular Weight

381.51

Formula

C22H23D7O5
Unlabeled CAS

83-43-2
Appearance

Solid

Color

White to off-white

SMILES

O=C1C([2H])=C[C@@]2([C@]3([C@]([2H])(C([2H])([C@@]4([C@@](C(CO)=O)(CC[C@]4([C@@]3(C[C@@]([2H])(C2=C1[2H])C)[H])[H])O)C)[2H])O)[2H])C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (327.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 125 mg/mL (327.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.26 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6212 mL 13.1058 mL 26.2116 mL
5 mM 0.5242 mL 2.6212 mL 5.2423 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.6212 mL 13.1058 mL 26.2116 mL 65.5291 mL
5 mM 0.5242 mL 2.6212 mL 5.2423 mL 13.1058 mL
10 mM 0.2621 mL 1.3106 mL 2.6212 mL 6.5529 mL
15 mM 0.1747 mL 0.8737 mL 1.7474 mL 4.3686 mL
20 mM 0.1311 mL 0.6553 mL 1.3106 mL 3.2765 mL
25 mM 0.1048 mL 0.5242 mL 1.0485 mL 2.6212 mL
30 mM 0.0874 mL 0.4369 mL 0.8737 mL 2.1843 mL
40 mM 0.0655 mL 0.3276 mL 0.6553 mL 1.6382 mL
50 mM 0.0524 mL 0.2621 mL 0.5242 mL 1.3106 mL
60 mM 0.0437 mL 0.2184 mL 0.4369 mL 1.0922 mL
80 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.8191 mL
100 mM 0.0262 mL 0.1311 mL 0.2621 mL 0.6553 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Methylprednisolone-d7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methylprednisolone-d7U 7532-d7Glucocorticoid ReceptorAutophagySARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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