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  4. MFN2 agonist-1

MFN2 agonist-1 (B-A/l) potently stimulates mitochondrial fusion in mitofusin 2 (MFN2)-deficient cells. MFN2 agonist-1 reverses mitochondrial “clumping” (formation of static mitochondrial aggregates) and restores mitochondrial motility in cultured mouse neurons expressing the CMT2A mutant MFN2 T105M.

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MFN2 agonist-1 Chemical Structure

MFN2 agonist-1 Chemical Structure

CAS No. : 2230047-87-5

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5 mg USD 255 In-stock
10 mg USD 410 In-stock
25 mg USD 820 In-stock
50 mg USD 1300 In-stock
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MFN2 agonist-1 Related Antibodies

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Description

MFN2 agonist-1 (B-A/l) potently stimulates mitochondrial fusion in mitofusin 2 (MFN2)-deficient cells. MFN2 agonist-1 reverses mitochondrial “clumping” (formation of static mitochondrial aggregates) and restores mitochondrial motility in cultured mouse neurons expressing the CMT2A mutant MFN2 T105M.

Molecular Weight

399.55

Formula

C21H29N5OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1C(C)CCCC1)NCCSC2=NN=C(C3CC3)N2C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (125.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5028 mL 12.5141 mL 25.0282 mL
5 mM 0.5006 mL 2.5028 mL 5.0056 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5028 mL 12.5141 mL 25.0282 mL 62.5704 mL
5 mM 0.5006 mL 2.5028 mL 5.0056 mL 12.5141 mL
10 mM 0.2503 mL 1.2514 mL 2.5028 mL 6.2570 mL
15 mM 0.1669 mL 0.8343 mL 1.6685 mL 4.1714 mL
20 mM 0.1251 mL 0.6257 mL 1.2514 mL 3.1285 mL
25 mM 0.1001 mL 0.5006 mL 1.0011 mL 2.5028 mL
30 mM 0.0834 mL 0.4171 mL 0.8343 mL 2.0857 mL
40 mM 0.0626 mL 0.3129 mL 0.6257 mL 1.5643 mL
50 mM 0.0501 mL 0.2503 mL 0.5006 mL 1.2514 mL
60 mM 0.0417 mL 0.2086 mL 0.4171 mL 1.0428 mL
80 mM 0.0313 mL 0.1564 mL 0.3129 mL 0.7821 mL
100 mM 0.0250 mL 0.1251 mL 0.2503 mL 0.6257 mL
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MFN2 agonist-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MFN2 agonist-12230047-87-5OthersInhibitorinhibitorinhibit

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