2. PI3K/Akt/mTOR Anti-infection
  3. PI4K HCV
  4. MI 14

MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a.

For research use only. We do not sell to patients.

MI 14 Chemical Structure

MI 14 Chemical Structure

CAS No. : 1715934-43-2

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Based on 1 publication(s) in Google Scholar

MI 14 Related Antibodies

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PI4KIIIβ PI4KIIIα PI4K PI4KII

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Description

MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a[1].

IC50 & Target[1]

PI4KIIIβ

54 nM (IC50)

PI4KIIIα

>100 μM (IC50)

PI4KIIα

>100 μM (IC50)

In Vitro

MI 14 (compound 36t) has antiviral activity against HCV 1b (EC50=0.087 µM), CVB3 (EC50=0.145 µM), HRVM (EC50=1.03 µM), HVC 2a (EC50=10.6 µM) in HeLa cells[1].
MI 14 has no inhibition on phosphatidylinositol 3-kinases (PI3Ka, PI3Kb, PI3Kd and PI3Kg) with IC50s up to 10 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MI 14 Related Antibodies
Molecular Weight

450.94

Formula

C19H23ClN6O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C)NCCNC1=CC(Cl)=NN2C1=NC(C)=C2C3=CC(S(=O)(N(C)C)=O)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.02 mg/mL (20.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2176 mL 11.0879 mL 22.1759 mL
5 mM 0.4435 mL 2.2176 mL 4.4352 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.3%

SDS (251 KB)

COA (251 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2176 mL 11.0879 mL 22.1759 mL 55.4397 mL
5 mM 0.4435 mL 2.2176 mL 4.4352 mL 11.0879 mL
10 mM 0.2218 mL 1.1088 mL 2.2176 mL 5.5440 mL
15 mM 0.1478 mL 0.7392 mL 1.4784 mL 3.6960 mL
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MI 14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI 141715934-43-2MI14MI-14PI4KHCVPhosphatidylinositol 4 kinasesPI4 kinasesHepatitis C virusAntiviralHCV 1bCVB3HRVMHVC 2aInhibitorinhibitorinhibit

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