Miconazole-d₅ nitrate  (Synonyms: R18134-d₅ nitrate)

Miconazole-d₅ (nitrate) is the deuterium labeled Miconazole. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

484.17

C₁₈H₁₀D₅Cl₄N₃O₄

1216653-51-8

22916-47-8

O=[N+](O)[O-].[2H]C(N1C=CN=C1)([2H])C(C2=C(C=C(C=C2)Cl)Cl)([2H])OC([2H])([2H])C3=C(C=C(C=C3)Cl)Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. http://en.wikipedia.org/wiki/Miconazole

  [3]. Nenoff P, et al. New insights on the antibacterial efficacy of miconazole in vitro. Mycoses. 2017 Aug;60(8):552-557.  [Content Brief]