2. Vitamin D Related/Nuclear Receptor Immunology/Inflammation Autophagy
  3. Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy
  4. Mifepristone-d3

Mifepristone-d3  (Synonyms: RU486-d3; RU 38486-d3)

Cat. No.: HY-13683S Purity: 97.51%
COA Handling Instructions

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Mifepristone-d3 is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

For research use only. We do not sell to patients.

Mifepristone-d<sub>3</sub> Chemical Structure

Mifepristone-d3 Chemical Structure

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1 mg USD 905 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Mifepristone-d3:

Mifepristone-d3 Related Antibodies

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nNOS iNOS eNOS

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Description

Mifepristone-d3 is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mifepristone-d3 Related Antibodies
Molecular Weight

432.61

Formula

C29H32D3NO2
Unlabeled CAS

84371-65-3
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@](C#CC)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(N(C)C([2H])([2H])[2H])C=C5)C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (231.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (231.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3116 mL 11.5578 mL 23.1155 mL
5 mM 0.4623 mL 2.3116 mL 4.6231 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.3116 mL 11.5578 mL 23.1155 mL 57.7888 mL
5 mM 0.4623 mL 2.3116 mL 4.6231 mL 11.5578 mL
10 mM 0.2312 mL 1.1558 mL 2.3116 mL 5.7789 mL
15 mM 0.1541 mL 0.7705 mL 1.5410 mL 3.8526 mL
20 mM 0.1156 mL 0.5779 mL 1.1558 mL 2.8894 mL
25 mM 0.0925 mL 0.4623 mL 0.9246 mL 2.3116 mL
30 mM 0.0771 mL 0.3853 mL 0.7705 mL 1.9263 mL
40 mM 0.0578 mL 0.2889 mL 0.5779 mL 1.4447 mL
50 mM 0.0462 mL 0.2312 mL 0.4623 mL 1.1558 mL
60 mM 0.0385 mL 0.1926 mL 0.3853 mL 0.9631 mL
80 mM 0.0289 mL 0.1445 mL 0.2889 mL 0.7224 mL
100 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5779 mL
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Mifepristone-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mifepristone-d3RU486-d3RU 38486-d3Progesterone ReceptorGlucocorticoid ReceptorNO SynthaseAutophagyNR3C3Nitric oxide synthasesNOSInhibitorinhibitorinhibit

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