(-)-Eseroline fumarate  (Synonyms: Eseroline fumarate)

(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum^[1][2].

(-)-Eseroline fumarate (0.5 mM; 0-25 hr) time-dependently induces LDH leakage of neuronal cell culture systems: mouse neuroblastoma N1E-115, rat glioma C6, and neuroblastoma-glioma hybrid NG 108-15^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Eseroline fumarate (HCl; 10 mg/kg; i.v.; single dose) induces the release of 5-HT from cerebral cortex in adult mongrel cats^[2].
(-)-Eseroline fumarate (salicylate; 9 mg/kg; s.c.; single dose) shows analgesic effect and strongly reduces antinociceptive effect of Physostigmine (HY-N6608) in the mouse tail-flick test^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

334.37

C₁₇H₂₂N₂O₅

70310-73-5

OC(/C=C/C(O)=O)=O.C[C@]12C3=CC(O)=CC=C3N([C@@]1([H])N(CC2)C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Somani SM, et al. Eseroline, a metabolite of physostigmine, induces neuronal cell death. Toxicol Appl Pharmacol. 1990 Oct;106(1):28-37.  [Content Brief]

  [2]. Bartolini A, et al. Eseroline: a new antinociceptive agent derived from physostigmine with opiate receptor agonist properties. Experimental in vivo and in vitro studies on cats and rodents. Neurosci Lett. 1981 Sep 1;25(2):179-83.  [Content Brief]

  [3]. Harris LS, et al. Narcotic-antagonist analgesics: interactions with cholinergic systems. J Pharmacol Exp Ther. 1969 Sep;169(1):17-22.  [Content Brief]