(-)-PX20606 (trans isomer) (Synonyms: (-)-PX-102 (trans isomer); (-)-PX-104)

Cat. No.: HY-100443B: FAQs
Data Sheet SDS Handling Instructions

Molarity Calculator

(-)-PX20606 trans isomer is a FXR agonist with EC₅₀s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

For research use only. We do not sell to patients.

(-)-PX20606 (trans isomer) Chemical Structure

CAS No. : 1268244-88-7

Size	Price	Stock
1 mg	USD 350	Ask For Quote & Lead Time
2 mg	USD 550	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of (-)-PX20606 (trans isomer):

trans-PX20606 In-stock
PX20606 Get quote

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Biological Activity
Purity & Documentation
References
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Description

(-)-PX20606 trans isomer is a FXR agonist with EC₅₀s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

IC₅₀ & Target

EC50: 18 nM (FXR in FRET assay), 29 nM (FXR in M1H assay)^[1]

Molecular Weight

554.85

Formula

C₂₉H₂₂Cl₃NO₄

CAS No.

1268244-88-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC1=C(C2=NOC(C3CC3)=C2COC4=CC=C([C@@H]5C[C@H]5C6=CC=C(C(O)=O)C=C6)C(Cl)=C4)C(Cl)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

Ethanol : ≥ 50 mg/mL (90.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8023 mL	9.0114 mL	18.0229 mL
5 mM	0.3605 mL	1.8023 mL	3.6046 mL
10 mM	0.1802 mL	0.9011 mL	1.8023 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (275 KB) SDS (135 KB) Handling Instructions (2659 KB)

References

[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	1.8023 mL	9.0114 mL	18.0229 mL	45.0572 mL
	5 mM	0.3605 mL	1.8023 mL	3.6046 mL	9.0114 mL
	10 mM	0.1802 mL	0.9011 mL	1.8023 mL	4.5057 mL
	15 mM	0.1202 mL	0.6008 mL	1.2015 mL	3.0038 mL
	20 mM	0.0901 mL	0.4506 mL	0.9011 mL	2.2529 mL
	25 mM	0.0721 mL	0.3605 mL	0.7209 mL	1.8023 mL
	30 mM	0.0601 mL	0.3004 mL	0.6008 mL	1.5019 mL
	40 mM	0.0451 mL	0.2253 mL	0.4506 mL	1.1264 mL
	50 mM	0.0360 mL	0.1802 mL	0.3605 mL	0.9011 mL
	60 mM	0.0300 mL	0.1502 mL	0.3004 mL	0.7510 mL
	80 mM	0.0225 mL	0.1126 mL	0.2253 mL	0.5632 mL

(-)-PX20606 (trans isomer) Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-PX20606 (trans isomer)1268244-88-7(-)-PX-102 (trans isomer) (-)-PX-104FXRAutophagyNR1H4Inhibitorinhibitorinhibit

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