2. Metabolic Enzyme/Protease Autophagy
  3. FXR Autophagy
  4. trans-PX20606

trans-PX20606  (Synonyms: trans-PX-102)

Cat. No.: HY-100443A Purity: 99.24%
COA Handling Instructions

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PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.

For research use only. We do not sell to patients.

trans-PX20606 Chemical Structure

trans-PX20606 Chemical Structure

CAS No. : 1268244-85-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 696 In-stock
Solution
10 mM * 1 mL in DMSO USD 696 In-stock
Solid
1 mg USD 144 In-stock
2 mg USD 228 In-stock
5 mg   Get quote  
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of trans-PX20606:

trans-PX20606 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE trans-PX20606

  • Biological Activity

  • Purity & Documentation

  • References

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Description

PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively[1].

IC50 & Target

EC50: 32 nM (FXR in FRET assay), 34 nM (FXR in M1H assay)[1]
Molecular Weight

554.85

Formula

C29H22Cl3NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C([C@H]2[C@H](C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3Cl)C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (180.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8023 mL 9.0114 mL 18.0229 mL
5 mM 0.3605 mL 1.8023 mL 3.6046 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.24%

COA (256 KB) RP-HPLC (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8023 mL 9.0114 mL 18.0229 mL 45.0572 mL
5 mM 0.3605 mL 1.8023 mL 3.6046 mL 9.0114 mL
10 mM 0.1802 mL 0.9011 mL 1.8023 mL 4.5057 mL
15 mM 0.1202 mL 0.6008 mL 1.2015 mL 3.0038 mL
20 mM 0.0901 mL 0.4506 mL 0.9011 mL 2.2529 mL
25 mM 0.0721 mL 0.3605 mL 0.7209 mL 1.8023 mL
30 mM 0.0601 mL 0.3004 mL 0.6008 mL 1.5019 mL
40 mM 0.0451 mL 0.2253 mL 0.4506 mL 1.1264 mL
50 mM 0.0360 mL 0.1802 mL 0.3605 mL 0.9011 mL
60 mM 0.0300 mL 0.1502 mL 0.3004 mL 0.7510 mL
80 mM 0.0225 mL 0.1126 mL 0.2253 mL 0.5632 mL
100 mM 0.0180 mL 0.0901 mL 0.1802 mL 0.4506 mL
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trans-PX20606 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

trans-PX206061268244-85-4trans-PX-102FXRAutophagyNR1H4Inhibitorinhibitorinhibit

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