MitoCur-1 

MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy^[1].

Thioredoxin reductase 2 (TrxR2)^[1]

MitoCur-1 exhibits selective cytotoxicity against HepG2 and L02 cells with IC50s of 1.4 μM and 9.1 μM, respectively^[1].
MitoCur-1 (10 μM; 12 h) generates ROS and depletes GSH selectively in HepG2 cells over L02 cells^[1].
MitoCur-1 (10 μM; 24 h) arrests cell cycle at G0/G1 phase, inhibits cyclin protein expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MitoCur-1 (5 mg/kg, 15 mg/kg; i.p.; every other day for 4 weeks) inhibits tumor growth in mouse model without effect on body weight^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1074.05

C₆₅H₆₄Cl₂O₆P₂

Solid

Light yellow to orange

O=C(C(C(/C=C/C1=CC=C(OCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(OC)=C1)=O)(C)C)/C=C/C5=CC(OC)=C(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)C=C5.[Cl-].[Cl-]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Zheng YL, et al. Redox-Based Strategy for Selectively Inducing Energy Crisis Inside Cancer Cells: An Example of Modifying Dietary Curcumin to Target Mitochondria. J Agric Food Chem. 2022 Mar 9;70(9):2898-2910.  [Content Brief]