2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Mivacurium dichloride

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell.

For research use only. We do not sell to patients.

Mivacurium dichloride Chemical Structure

Mivacurium dichloride Chemical Structure

CAS No. : 106861-44-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 124 In-stock
Solution
10 mM * 1 mL in DMSO USD 124 In-stock
Solid
1 mg USD 31 In-stock
5 mg USD 77 In-stock
10 mg USD 110 In-stock
25 mg USD 160 In-stock
50 mg USD 253 In-stock
100 mg USD 385 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Mivacurium dichloride:

Mivacurium dichloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell[1][2][3].

In Vitro

Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mivacurium dichloride Related Antibodies
In Vivo

Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature[1].
Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

1100.17

Formula

C58H80Cl2N2O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCCC[N+]1(C)[C@H](CC2=CC(OC)=C(OC)C(OC)=C2)C3=C(C=C(OC)C(OC)=C3)CC1)CC/C=C/CCC(OCCC[N+]4(C)[C@H](CC5=CC(OC)=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4)=O.[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (227.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (90.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9090 mL 4.5448 mL 9.0895 mL
5 mM 0.1818 mL 0.9090 mL 1.8179 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.35%

COA (248 KB) HNMR (338 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.9090 mL 4.5448 mL 9.0895 mL 22.7238 mL
5 mM 0.1818 mL 0.9090 mL 1.8179 mL 4.5448 mL
10 mM 0.0909 mL 0.4545 mL 0.9090 mL 2.2724 mL
15 mM 0.0606 mL 0.3030 mL 0.6060 mL 1.5149 mL
20 mM 0.0454 mL 0.2272 mL 0.4545 mL 1.1362 mL
25 mM 0.0364 mL 0.1818 mL 0.3636 mL 0.9090 mL
30 mM 0.0303 mL 0.1515 mL 0.3030 mL 0.7575 mL
40 mM 0.0227 mL 0.1136 mL 0.2272 mL 0.5681 mL
50 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.4545 mL
60 mM 0.0151 mL 0.0757 mL 0.1515 mL 0.3787 mL
80 mM 0.0114 mL 0.0568 mL 0.1136 mL 0.2840 mL
DMSO 100 mM 0.0091 mL 0.0454 mL 0.0909 mL 0.2272 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mivacurium dichloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mivacurium dichloride106861-44-3nAChRNicotinic acetylcholine receptorsShort-durationnon-depolarizingbenzylisoquinolinesteroidalneuromuscularskeletalmusclerelaxantInhibitorinhibitorinhibit

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