2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. MK-1084

MK-1084 is a selective KRAS G12C inhibitor that is currently in Phase I clinical trial (NCT05067283). MK-1084 exhibits anticancer activity and can be used either alone or in combination with pembrolizumab (HY-P9902) for cancer research.

For research use only. We do not sell to patients.

MK-1084 Chemical Structure

MK-1084 Chemical Structure

CAS No. : 2641216-67-1

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1 mg USD 1140 In-stock
5 mg USD 2850 In-stock
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Based on 1 publication(s) in Google Scholar

MK-1084 Related Antibodies

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Description

MK-1084 is a selective KRAS G12C inhibitor that is currently in Phase I clinical trial (NCT05067283). MK-1084 exhibits anticancer activity and can be used either alone or in combination with pembrolizumab (HY-P9902) for cancer research[1].

Molecular Weight

637.08

Formula

C32H31ClF2N6O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C2C(OCCOC3=CC=NC(C(C)C)=C3N4C5=NC2=C(Cl)C=C5C(N6[C@@H](C)CN(C(C=C)=O)[C@H](C)C6)=NC4=O)=C(F)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (156.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5697 mL 7.8483 mL 15.6966 mL
5 mM 0.3139 mL 1.5697 mL 3.1393 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5697 mL 7.8483 mL 15.6966 mL 39.2415 mL
5 mM 0.3139 mL 1.5697 mL 3.1393 mL 7.8483 mL
10 mM 0.1570 mL 0.7848 mL 1.5697 mL 3.9242 mL
15 mM 0.1046 mL 0.5232 mL 1.0464 mL 2.6161 mL
20 mM 0.0785 mL 0.3924 mL 0.7848 mL 1.9621 mL
25 mM 0.0628 mL 0.3139 mL 0.6279 mL 1.5697 mL
30 mM 0.0523 mL 0.2616 mL 0.5232 mL 1.3081 mL
40 mM 0.0392 mL 0.1962 mL 0.3924 mL 0.9810 mL
50 mM 0.0314 mL 0.1570 mL 0.3139 mL 0.7848 mL
60 mM 0.0262 mL 0.1308 mL 0.2616 mL 0.6540 mL
80 mM 0.0196 mL 0.0981 mL 0.1962 mL 0.4905 mL
100 mM 0.0157 mL 0.0785 mL 0.1570 mL 0.3924 mL
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MK-1084 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-10842641216-67-1MK1084MK 1084RasInhibitorinhibitorinhibit

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