2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. ML 10302

ML 10302 is a potent agonist 5-HT4 receptor with Ki of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases.

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ML 10302 Chemical Structure

ML 10302 Chemical Structure

CAS No. : 148868-55-7

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Based on 1 publication(s) in Google Scholar

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

ML 10302 is a potent agonist 5-HT4 receptor with Ki of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases[1].

Cellular Effect
Cell Line Type Value Description References
C6 EC50
51 nM
Compound: ML-10302
Agonist activity at human 5HT4 isoform E receptor expressed in rat C6 cells assessed as cAMP accumulation by radio-immunoassay relative to 5HT
Agonist activity at human 5HT4 isoform E receptor expressed in rat C6 cells assessed as cAMP accumulation by radio-immunoassay relative to 5HT
[PMID: 19334715]
CHO EC50
2.5 nM
Compound: ML-10302
Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assay
Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assay
[PMID: 26363507]
Molecular Weight

312.79

Formula

C15H21ClN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (399.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1970 mL 15.9852 mL 31.9703 mL
5 mM 0.6394 mL 3.1970 mL 6.3941 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1970 mL 15.9852 mL 31.9703 mL 79.9258 mL
5 mM 0.6394 mL 3.1970 mL 6.3941 mL 15.9852 mL
10 mM 0.3197 mL 1.5985 mL 3.1970 mL 7.9926 mL
15 mM 0.2131 mL 1.0657 mL 2.1314 mL 5.3284 mL
20 mM 0.1599 mL 0.7993 mL 1.5985 mL 3.9963 mL
25 mM 0.1279 mL 0.6394 mL 1.2788 mL 3.1970 mL
30 mM 0.1066 mL 0.5328 mL 1.0657 mL 2.6642 mL
40 mM 0.0799 mL 0.3996 mL 0.7993 mL 1.9981 mL
50 mM 0.0639 mL 0.3197 mL 0.6394 mL 1.5985 mL
60 mM 0.0533 mL 0.2664 mL 0.5328 mL 1.3321 mL
80 mM 0.0400 mL 0.1998 mL 0.3996 mL 0.9991 mL
100 mM 0.0320 mL 0.1599 mL 0.3197 mL 0.7993 mL
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ML 10302 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML 10302148868-55-7ML10302ML-103025-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT4gut motilitycholinergicprokinesianeurologyInhibitorinhibitorinhibit

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