2. Epigenetics
  3. MicroRNA
  4. mmu-miR-6378 antagomir

mmu-miR-6378 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

For research use only. We do not sell to patients.

RNA, (GCGUGUGUCCUCCCGUGAAC) (2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification)

mmu-miR-6378 antagomir Chemical Structure

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5 nmol USD 225 Get quote 1-2 weeks 1-2 weeks 1-2 weeks
20 nmol USD 450 Get quote 1-2 weeks 1-2 weeks 1-2 weeks
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Based on 1 publication(s) in Google Scholar

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mmu-miR-6378 antagomir Related Antibodies

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Description

mmu-miR-6378 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

Molecular Weight

7334.73

miRBase Accession Number
Mature miRNA Sequence

UGGUUCACGGGAGGACACACGC

Stem-loop ID

mmu-mir-6378

Stem-loop Sequence

UCUCGCAUGGUUCACGGGAGGACACACGCGUUUCUGUUGGUGAUUGGGGAGCCUGCCUUUGUUCCCACAUUGUAAGGAACUGCCUGAUUUUCUCUGAAAUAUGGAGU

Species

Mouse

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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mmu-miR-6378 antagomir Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mmu-miR-6378 antagomirMicroRNAmiRNAInhibitorinhibitorinhibit

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