Vc-seco-DUBA (Synonyms: SYD985)

Name: Vc-seco-DUBA
Brand: MedChemExpress
SKU: HY-128957
Rating: 4.5 (1 reviews)

Cat. No.: HY-128957 Purity: 99.95%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Vc-seco-DUBA (SYD985) is a agent-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco.

For research use only. We do not sell to patients.

Vc-seco-DUBA Chemical Structure

CAS No. : 1345681-58-4

Size	Price	Stock	Quantity
1 mg	USD 2500	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 6500	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 10800	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Vc-seco-DUBA

•Patent. US20240245798A1.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Vc-seco-DUBA (SYD985) is a agent-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco^[1].

IC₅₀ & Target^[1]

Duocarmycins

Clinical Trial

Molecular Weight

1331.81

Formula

C₆₅H₇₅ClN₁₂O₁₇

CAS No.

1345681-58-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCCOCCN2C(C=CC2=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C1)N(C)CCN(C(OC3=CC(N(C[C@H]4CCl)C(C5=CN6C=C(C=CC6=N5)NC(C(C=C7)=CC=C7O)=O)=O)=C4C8=C(C)C=CC=C83)=O)CCOCCO

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light, stored under nitrogen

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (75.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7509 mL	3.7543 mL	7.5086 mL
5 mM	0.1502 mL	0.7509 mL	1.5017 mL
10 mM	0.0751 mL	0.3754 mL	0.7509 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.44 mg/mL (1.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.44 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (24.4 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.44 mg/mL (1.83 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.44 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (24.4 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.44 mg/mL (1.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.44 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (24.4 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB) HNMR (286 KB) RP-HPLC (260 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

References

[1]. Samantha Congreve, et al. Antibody drug conjugates (ADC) Current status and mapping of ADC:s in clinical programs.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7509 mL	3.7543 mL	7.5086 mL	18.7714 mL
	5 mM	0.1502 mL	0.7509 mL	1.5017 mL	3.7543 mL
	10 mM	0.0751 mL	0.3754 mL	0.7509 mL	1.8771 mL
	15 mM	0.0501 mL	0.2503 mL	0.5006 mL	1.2514 mL
	20 mM	0.0375 mL	0.1877 mL	0.3754 mL	0.9386 mL
	25 mM	0.0300 mL	0.1502 mL	0.3003 mL	0.7509 mL
	30 mM	0.0250 mL	0.1251 mL	0.2503 mL	0.6257 mL
	40 mM	0.0188 mL	0.0939 mL	0.1877 mL	0.4693 mL
	50 mM	0.0150 mL	0.0751 mL	0.1502 mL	0.3754 mL
	60 mM	0.0125 mL	0.0626 mL	0.1251 mL	0.3129 mL

Vc-seco-DUBA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vc-seco-DUBA1345681-58-4SYD985SYD 985SYD-985Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Vc-seco-DUBA (Synonyms: SYD985)

Customer Review

Vc-seco-DUBA Related Antibodies

1 Publications Citing Use of MCE Vc-seco-DUBA

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Vc-seco-DUBA Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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