2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Monoethylglycinexylidide hydrochloride

Monoethylglycinexylidide hydrochloride  (Synonyms: MEGX hydrochloride; Norlidocaine hydrochloride)

Cat. No.: HY-W099331
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Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation.

For research use only. We do not sell to patients.

Monoethylglycinexylidide hydrochloride Chemical Structure

Monoethylglycinexylidide hydrochloride Chemical Structure

CAS No. : 7729-94-4

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Other Forms of Monoethylglycinexylidide hydrochloride:

Monoethylglycinexylidide hydrochloride Related Antibodies

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Description

Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation[1][2].

Molecular Weight

242.75

Formula

C12H19ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCNCC(NC1=C(C)C=CC=C1C)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 5 mg/mL (20.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1195 mL 20.5973 mL 41.1946 mL
5 mM 0.8239 mL 4.1195 mL 8.2389 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1195 mL 20.5973 mL 41.1946 mL 102.9866 mL
5 mM 0.8239 mL 4.1195 mL 8.2389 mL 20.5973 mL
10 mM 0.4119 mL 2.0597 mL 4.1195 mL 10.2987 mL
15 mM 0.2746 mL 1.3732 mL 2.7463 mL 6.8658 mL
20 mM 0.2060 mL 1.0299 mL 2.0597 mL 5.1493 mL
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Monoethylglycinexylidide hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monoethylglycinexylidide7729-94-4MEGXNorlidocaineDrug MetaboliteInhibitorinhibitorinhibit

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