2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. HIV Reactive Oxygen Species NOD-like Receptor (NLR)
  4. Moronic acid

Moronic acid  (Synonyms: (+)-Moronic acid)

Cat. No.: HY-N3242 Purity: 98.6%
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Moronic Acid is a triterpenoid compound, which is an orally available anti-HIV agent with anti-inflammatory activity. Moronic Acid can inhibit viral replication, with an EC50 value of <1 μg/mL. Moronic Acid can be isolated from Brazilian propolis.

For research use only. We do not sell to patients.

Moronic acid Chemical Structure

Moronic acid Chemical Structure

CAS No. : 6713-27-5

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Moronic acid Related Antibodies

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  • Biological Activity

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Description

Moronic Acid is a triterpenoid compound, which is an orally available anti-HIV agent with anti-inflammatory activity. Moronic Acid can inhibit viral replication, with an EC50 value of <1 μg/mL. Moronic Acid can be isolated from Brazilian propolis[1][2][3].

IC50 & Target

NLRP3

 

In Vitro

Moronic Acid is cytotoxic to H9 lymphocytes, with an IC50 value of 18.6 μg/mL[1].
Moronic Acid (10-20 μM) inhibits the polarization of intestinal macrophages to M1, reducing ROS levels as well as the expression of p-P50 and NLRP3 proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Moronic acid Related Antibodies

Western Blot Analysis[2]

Cell Line: Intestinal macrophages
Concentration: 10, 20 μM
Incubation Time:
Result: Reduced expression of p-P50 and NLRP3 proteins.
In Vivo

Moronic Acid (5-10 mg/kg, i.g., once daily, 20 days) regulates the ROS - NF - κB - NLRP3 signaling pathway in mice by inhibiting ROS, improving inflammatory bowel disease[2].
Moronic Acid extends the survival time of HSV-1 infected mice and slows the progression of skin lesions[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice induced by DSS[2]
Dosage: 5, 10 mg/kg; daily; 20 days
Administration: i.g.
Result: Inhibited intestinal macrophage M1 polarization, inhibited the expression of inflammatory factors, and reduced ROS-NF-κB-NLRP3 signaling levels.
Molecular Weight

454.68

Formula

C30H46O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@]3([C@@](CC[C@]1([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC2)C)([H])C5=CC(C)(C)CC[C@@]5(CC3)C(O)=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 18.6 mg/mL (40.91 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1993 mL 10.9967 mL 21.9935 mL
5 mM 0.4399 mL 2.1993 mL 4.3987 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.6%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1993 mL 10.9967 mL 21.9935 mL 54.9837 mL
5 mM 0.4399 mL 2.1993 mL 4.3987 mL 10.9967 mL
10 mM 0.2199 mL 1.0997 mL 2.1993 mL 5.4984 mL
15 mM 0.1466 mL 0.7331 mL 1.4662 mL 3.6656 mL
20 mM 0.1100 mL 0.5498 mL 1.0997 mL 2.7492 mL
25 mM 0.0880 mL 0.4399 mL 0.8797 mL 2.1993 mL
30 mM 0.0733 mL 0.3666 mL 0.7331 mL 1.8328 mL
40 mM 0.0550 mL 0.2749 mL 0.5498 mL 1.3746 mL
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Moronic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moronic acid6713-27-5(+)-Moronic acidHIVReactive Oxygen SpeciesNOD-like Receptor (NLR)Human immunodeficiency virustriterpenoidviral replicationanti-inflammatoryInhibitorinhibitorinhibit

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