MPC-3100

Cat. No.: HY-13301 Purity: 98.3%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with potential antineoplastic activity.

For research use only. We do not sell to patients.

MPC-3100 Chemical Structure

CAS No. : 958025-66-6

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

Biological Activity
Purity & Documentation
References
Customer Review

Description

MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with potential antineoplastic activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.77 μM Compound: 28g, MPC-3100	Cytotoxicity against human A549 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human A549 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
BT-474	IC₅₀	0.55 μM Compound: 28g, MPC-3100	Cytotoxicity against human BT474 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human BT474 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
DU-145	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in DU145 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method Inhibition of human HSP90 in DU145 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method	[PMID: 22913511]
DU-145	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in DU145 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method Inhibition of human HSP90 in DU145 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method	[PMID: 22913511]
DU-145	IC₅₀	0.53 μM Compound: 28g, MPC-3100	Cytotoxicity against human DU145 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human DU145 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
HCT-116	IC₅₀	0.06 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in HCT116 cells expressing Her2 gene assessed as degradation of Her2 after 4 hrs by luciferase reporter gene assay Inhibition of human HSP90 in HCT116 cells expressing Her2 gene assessed as degradation of Her2 after 4 hrs by luciferase reporter gene assay	[PMID: 22913511]
HCT-116	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in HCT116 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method Inhibition of human HSP90 in HCT116 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method	[PMID: 22913511]
HCT-116	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in HCT116 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method Inhibition of human HSP90 in HCT116 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method	[PMID: 22913511]
HCT-116	IC₅₀	0.54 μM Compound: 28g, MPC-3100	Cytotoxicity against human HCT116 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human HCT116 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
HT-29	IC₅₀	0.42 μM Compound: 28g, MPC-3100	Cytotoxicity against human HT-29 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human HT-29 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
LNCaP	IC₅₀	0.51 μM Compound: 28g, MPC-3100	Cytotoxicity against human LNCAP cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human LNCAP cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
MV4-11	IC₅₀	0.25 μM Compound: 28g, MPC-3100	Cytotoxicity against human MV4-11 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human MV4-11 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
NCI/ADR-RES	IC₅₀	4.3 μM Compound: 28g, MPC-3100	Cytotoxicity against human NCI-ADR-RES cells overexpressing P-gp 1 assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human NCI-ADR-RES cells overexpressing P-gp 1 assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
NCI-H69	IC₅₀	0.15 μM Compound: 28g, MPC-3100	Cytotoxicity against human NCI-H69 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human NCI-H69 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
NCI-N87	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in NCI-N87 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method Inhibition of human HSP90 in NCI-N87 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method	[PMID: 22913511]
NCI-N87	IC₅₀	0.2 μM Compound: 28g, MPC-3100	Cytotoxicity against human NCI-N87 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human NCI-N87 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
OVCAR-8	IC₅₀	0.49 μM Compound: 28g, MPC-3100	Cytotoxicity against human OVCAR8 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human OVCAR8 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]

Molecular Weight

549.44

Formula

C₂₂H₂₅BrN₆O₄S

CAS No.

958025-66-6

Appearance

Solid

Color

White to off-white

SMILES

NC1=C2C(N(CCC3CCN(C([C@@H](O)C)=O)CC3)C(SC4=C(Br)C=C(OCO5)C5=C4)=N2)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5.5 mg/mL (10.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8200 mL	9.1002 mL	18.2003 mL
5 mM	0.3640 mL	1.8200 mL	3.6401 mL
10 mM	0.1820 mL	0.9100 mL	1.8200 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.3%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (255 KB)

Handling Instructions (2659 KB)

References

[1]. Kim SH, et al. Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor. J Med Chem. 2012 Sep 13;55(17):7480-501. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8200 mL	9.1002 mL	18.2003 mL	45.5009 mL
	5 mM	0.3640 mL	1.8200 mL	3.6401 mL	9.1002 mL
	10 mM	0.1820 mL	0.9100 mL	1.8200 mL	4.5501 mL

MPC-3100 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPC-3100958025-66-6MPC3100MPC 3100HSPHeat shock proteinsInhibitorinhibitorinhibit

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MPC-3100

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MPC-3100 Related Antibodies

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References

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Complete Stock Solution Preparation Table

MPC-3100 Related Classifications

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