2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. mSIRK

mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

mSIRK Chemical Structure

mSIRK Chemical Structure

CAS No. : 593267-11-9

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Based on 1 publication(s) in Google Scholar

Other Forms of mSIRK:

mSIRK Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE mSIRK

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

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Description

mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange[1].

Molecular Weight

1948.31

Formula

C93H150N20O25
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Myr}-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp
Sequence Shortening

{Myr}-SIRKALNILGYPDYD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (51.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5133 mL 2.5663 mL 5.1327 mL
5 mM 0.1027 mL 0.5133 mL 1.0265 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.03%

SDS (252 KB)

COA (248 KB) RP-HPLC (205 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5133 mL 2.5663 mL 5.1327 mL 12.8316 mL
5 mM 0.1027 mL 0.5133 mL 1.0265 mL 2.5663 mL
10 mM 0.0513 mL 0.2566 mL 0.5133 mL 1.2832 mL
15 mM 0.0342 mL 0.1711 mL 0.3422 mL 0.8554 mL
20 mM 0.0257 mL 0.1283 mL 0.2566 mL 0.6416 mL
25 mM 0.0205 mL 0.1027 mL 0.2053 mL 0.5133 mL
30 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.4277 mL
40 mM 0.0128 mL 0.0642 mL 0.1283 mL 0.3208 mL
50 mM 0.0103 mL 0.0513 mL 0.1027 mL 0.2566 mL
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mSIRK Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mSIRK593267-11-9ERKExtracellular signal regulated kinasesERK1/2 activatorG-ProteinInhibitorinhibitorinhibit

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