MSN8C 

MSN8C, an analog of mansonone E, is a novel catalytic inhibitor of human DNA topoisomerase II. MSN8C induces cancer cell apoptosis. MSN8C shows significant anti-tumor cell proliferation activity in vitro^[1].

MSN8C prevents supercoiled DNA from entering the catalytic cycle to avoid capture by Topo II poisons and reduces fragmented DNA generation^[1].
MSN8C (1-10 μM, 24 h) induces HL-60 cancer cell apoptosis via increases caspases-3 expression in a dose-dependent manner.^[1].
MSN8C (1, 5, 10, 20 μM, 12 h) increases caspase-8 and caspase-9 activity in HL-60 cells^[1].
MSN8C (48 h) inhibits human 11 tumor cell lines from various origins with an average IC₅₀ value of 2.6 µM^[1].
MSN8C has strong antiproliferative effects on the human breast cancer adriamycin (HY-15142)-resistant cell line MCF-7/Adr and mitoxantrone (HY-13502)-resistant cell line HL-60/MX2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MSN8C (10 mg/kg, i.p, two-day intervals for 2 weeks) in a A549 tumor xenograft model inhibits tumor growth with less toxic^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

214.22

C₁₃H₁₀O₃

1314798-31-6

CC(CO1)C2=C(C1=CC(C3=O)=O)C3=CC=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jie-Bin Ou, et al. MSN8C: A Promising Candidate for Antitumor Applications as a Novel Catalytic Inhibitor of Topoisomerase II. Molecules. 2023 Jul, 28(14).