2. PROTAC Vitamin D Related/Nuclear Receptor Apoptosis
  3. PROTACs Androgen Receptor Apoptosis
  4. MTX-23

MTX-23  (Synonyms: PROTAC AR-V7 degrader-2)

Cat. No.: HY-148771 Purity: 99.90%
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MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis.

For research use only. We do not sell to patients.

MTX-23 Chemical Structure

MTX-23 Chemical Structure

CAS No. : 2488296-74-6

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5 mg USD 400 In-stock
10 mg USD 630 In-stock
25 mg USD 1200 In-stock
50 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

MTX-23 Related Antibodies

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Description

MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis[1].

In Vitro

MTX-23 (compound 16; 0-20 μM; 4 d; 22Rvl cells) inhibits cell growth in dose-dependent manner[1].
MTX-23 (10 μM; 4 d; 22Rvl cells) reduces AR-V7 protein levels[1].
MTX-23 (1 μM; 0-48 h; 22Rvl cells) induces apoptosis and increases annexin-V staining[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MTX-23 Related Antibodies

Cell Viability Assay[1]

Cell Line: 22Rvl cells
Concentration: 0-20 μM
Incubation Time: 4 days
Result: Reduced the cell count by less than 50 percent.

Apoptosis Analysis[1]

Cell Line: 22Rvl cells
Concentration: 1 μM
Incubation Time: 0-48 h
Result: Induced cell apoptosis in 22Rvl cells.

Western Blot Analysis[1]

Cell Line: 22Rvl cells
Concentration: 10 μM
Incubation Time: 4 days
Result: Reduced AR-V7 protein levels.
In Vivo

MTX-23 (compound 16; 2.5 mg/mL; intratumor injection) inhibits tumor growth in nu/nu mice with 22Rvl-EnzR tumor xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: nu/nu mice with 22Rvl-EnzR tumor xenografts[1]
Dosage: 2.5 mg/mL
Administration: intratumor injection
Result: Inhibited tumor growth in nu/nu mice with 22Rvl-EnzR tumor xenografts.
Molecular Weight

882.05

Formula

C43H53F2N7O7S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (113.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1337 mL 5.6686 mL 11.3372 mL
5 mM 0.2267 mL 1.1337 mL 2.2674 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1337 mL 5.6686 mL 11.3372 mL 28.3431 mL
5 mM 0.2267 mL 1.1337 mL 2.2674 mL 5.6686 mL
10 mM 0.1134 mL 0.5669 mL 1.1337 mL 2.8343 mL
15 mM 0.0756 mL 0.3779 mL 0.7558 mL 1.8895 mL
20 mM 0.0567 mL 0.2834 mL 0.5669 mL 1.4172 mL
25 mM 0.0453 mL 0.2267 mL 0.4535 mL 1.1337 mL
30 mM 0.0378 mL 0.1890 mL 0.3779 mL 0.9448 mL
40 mM 0.0283 mL 0.1417 mL 0.2834 mL 0.7086 mL
50 mM 0.0227 mL 0.1134 mL 0.2267 mL 0.5669 mL
60 mM 0.0189 mL 0.0945 mL 0.1890 mL 0.4724 mL
80 mM 0.0142 mL 0.0709 mL 0.1417 mL 0.3543 mL
100 mM 0.0113 mL 0.0567 mL 0.1134 mL 0.2834 mL
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MTX-23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTX-232488296-74-6PROTAC AR-V7 degrader-2MTX23MTX 23PROTACsAndrogen ReceptorApoptosisPROTACAR-V7AR-FLCaP cellularInhibitorinhibitorinhibit

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