2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. MU380

MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity.

For research use only. We do not sell to patients.

MU380 Chemical Structure

MU380 Chemical Structure

CAS No. : 2109805-78-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

MU380 Related Antibodies

Top Publications Citing Use of Products

View All Checkpoint Kinase (Chk) Isoform Specific Products:

View All Isoforms
Chk1 Chk2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity[1].

In Vitro

MU380 (100 nM, 24 h) potently inhibits CHK1 kinase and sensitizes lymphoid tumor cells to gemcitabine[1].
MU380 (400 nM, 24 h) can significantly affect the cell cycle profile and induce the death of dividing and non-dividing primary chronic lymphocytic leukemia lymphocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MU380 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MEC-1and MEC-2 cells
Concentration: 400 nM
Incubation Time: 24 h
Result: Showed accumulation in S phase as well as reduction in G2/M phase, greatly reduced rate of DNA synthesis, and marked induction of apoptosis (PARP protein cleavage).

Western Blot Analysis[1]

Cell Line: Chronic lymphocytic leukemia cells
Concentration: 100 nM or 200 nM
Incubation Time: 24 h
Result: Potently blocked CHK1 activation while enhancing ATR kinase signaling to CHK1 (pS317 and pS345), and resulted in decreased levels of total CDC25A and CDC25C, pY15 CDK1, cyclin B1 and cyclin E1.
In Vivo

MU380 (20 mg/kg, in 20% aqueous Kolliphor solution, every three days from day 14 to day 28) can effectively inhibit tumor growth in NOD-scid IL2Rγnull mice with tumour[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-scid IL2Rγnull mice[1]
Dosage: 20 mg/kg
Administration: In 20% aqueous Kolliphor solution, every three days from day 14 to day 28
Result: Significantly inhibit the growth of tumors and gradually reduce their volume, with an average reduction of about 61%.
Molecular Weight

430.23

Formula

C15H15BrF3N7
CAS No.
SMILES

NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C(F)(F)F)N=C4)C=NN13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MU380 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU3802109805-78-7MU 380MU-380Checkpoint Kinase (Chk)CHK1apoptosisanticancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MU380
Cat. No.:
HY-112927
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.