2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis c-Met/HGFR PDGFR Src TAM Receptor
  4. Multi-kinase-IN-1

Multi-kinase-IN-1 (Compound 11k) is a potent kinase inhibitor with antitumor activity. Multi-kinase-IN-1 induces cell apoptosis, and can be studied for colorectal cancer.

For research use only. We do not sell to patients.

Multi-kinase-IN-1 Chemical Structure

Multi-kinase-IN-1 Chemical Structure

CAS No. : 2470807-67-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Multi-kinase-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All PDGFR Isoform Specific Products:

View All Isoforms
PDGFR PDGFRβ PDGFRα

View All Src Isoform Specific Products:

View All Isoforms
Lck Fyn Blk

View All TAM Receptor Isoform Specific Products:

View All Isoforms
Axl Mer Tyro3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Multi-kinase-IN-1 (Compound 11k) is a potent kinase inhibitor with antitumor activity. Multi-kinase-IN-1 induces cell apoptosis, and can be studied for colorectal cancer[1].

IC50 & Target

Ron

0.122 μM (IC50)

PDGFRα

0.384 μM (IC50)

c-Src

0.421 μM (IC50)

AXL

0.632 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HT-29 IC50
0.31 μM
Compound: 11k
Anticancer activity against human HT-29 cells assessed as inhibition of cell proliferation by MTT assay
Anticancer activity against human HT-29 cells assessed as inhibition of cell proliferation by MTT assay
[PMID: 32731184]
In Vitro

Multi-kinase-IN-1 (Compound 11k) (0-5 µg/mL, 0-72 h) induces antiproliferation and cytotoxicity in a dose- and time-dependent manner in HT-29 cells, and is much less toxic to normal colorectal mucosa epithelial cells[1].
Multi-kinase-IN-1 (0-3 µg/mL, 0-72 h) induces cell apoptosis in a time- and dose-dependent manner[1].
Multi-kinase-IN-1 (0-3 µg/mL, 48 h) slightly induces cell cycle arrest in G2/M phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Multi-kinase-IN-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HT-29 (human colon cancer cell) and FHC (normal colorectal mucosa epithelial cells)
Concentration: 0.56, 1.67, and 5 µg/mL for HT-29, 10 µg/mL for FHC
Incubation Time: 0-72 h
Result: Led to significant cytotoxicity in a dose- and time-dependent manner in HT-29 cells. Showed low toxicity in FHC cells.

Apoptosis Analysis[1]

Cell Line: HT-29
Concentration: 0.3, 1, and 3 µg/mL
Incubation Time: 0-72 h
Result: Induced cell apoptosis in a time- and dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HT-29
Concentration: 0.3, 1, and 3 µg/mL
Incubation Time: 48 h
Result: Slightly induced cell cycle arrest with a G2/M percentage of 4.4% at 3.0 mg/mL compared to 0.1% DMSO (2.4%).
Molecular Weight

706.76

Formula

C35H36F2N6O6S
CAS No.
SMILES

O=C(N1CCC(OC2=C(OC)C=C3C(OC4=CC=C(NC(NN5C(C6=C(F)C=CC=C6F)SCC5=O)=O)C=C4)=CC=NC3=C2)CC1)NC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Multi-kinase-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-12470807-67-9Apoptosisc-Met/HGFRPDGFRSrcTAM ReceptorPlatelet-derived growth factor receptorTyro3AxlMerantitumorHT-29low toxicityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Multi-kinase-IN-1
Cat. No.:
HY-146014
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.