Muscarine (Synonyms: (+)-Muscarine)

Cat. No.: HY-121404: FAQs
Data Sheet Handling Instructions

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Muscarine ((+)-Muscarine) is an agonist of prototype mAChR. Muscarine is a toxin that can stimulate the parasympathetic nervous system.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Muscarine chloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Muscarine Chemical Structure

CAS No. : 300-54-9

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Other Forms of Muscarine:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

Muscarine ((+)-Muscarine) is an agonist of prototype mAChR. Muscarine is a toxin that can stimulate the parasympathetic nervous system^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	130 nM Compound: Muscarine	Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3 Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3	[PMID: 9622546]
CHO	EC₅₀	219 nM Compound: Muscarine	Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1 Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1	[PMID: 9622546]
CHO	IC₅₀	470 nM Compound: Muscarine	Inhibitory activity against [3H]-cyclic AMP accumulation in CHO transfected cells mediated by Muscarinic acetylcholine receptor M4 Inhibitory activity against [3H]-cyclic AMP accumulation in CHO transfected cells mediated by Muscarinic acetylcholine receptor M4	[PMID: 9622546]

In Vitro

Muscarine (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM acetylcholine in brain miero vascular endothelial cells (BMVECs) and brain-derived Endothelial cells.3 (bEnd.3)^[1].
Muscarine (1-30 μM; 2 min) produces a dose-dependent hyperpolarization in a sub-population of the nucleus raphe magnus (NRM) cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons with an EC₅₀ value of 2.7 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

174.26

Formula

C₉H₂₀NO₂⁺

CAS No.

300-54-9

SMILES

C[C@H]1[C@@H](C[C@H](O1)C[N+](C)(C)C)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083. [Content Brief]

[2]. Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8. [Content Brief]

Muscarine Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muscarine300-54-9(+)-MuscarinemAChRMuscarinic acetylcholine receptorIntracellular calciumNRMNeuronInhibitorinhibitorinhibit

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