2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Muscarine chloride

Muscarine chloride  (Synonyms: (+)-Muscarine chloride)

Cat. No.: HY-121404A Purity: ≥99.0%
COA Handling Instructions

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Muscarine ((+)-Muscarine) chloride is an agonist of prototype mAChR. Muscarine chloride is a toxin that can stimulate the parasympathetic nervous system.

For research use only. We do not sell to patients.

Muscarine chloride Chemical Structure

Muscarine chloride Chemical Structure

CAS No. : 2303-35-7

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5 mg USD 960 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Muscarine chloride:

Muscarine chloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Muscarine ((+)-Muscarine) chloride is an agonist of prototype mAChR. Muscarine chloride is a toxin that can stimulate the parasympathetic nervous system[1][2].

In Vitro

Muscarine chloride (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM acetylcholine in brain miero vascular endothelial cells (BMVECs) and brain-derived Endothelial cells.3 (bEnd.3)[1].
Muscarine chloride (1-30 μM; 2 min) produces a dose-dependent hyperpolarization in a sub-population of the nucleus raphe magnus (NRM) cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons with an EC50 value of 2.7 µM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Muscarine chloride Related Antibodies
Molecular Weight

209.71

Formula

C9H20ClNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1[C@@H](C[C@H](O1)C[N+](C)(C)C)O.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (238.42 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7685 mL 23.8424 mL 47.6849 mL
5 mM 0.9537 mL 4.7685 mL 9.5370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (248 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.7685 mL 23.8424 mL 47.6849 mL 119.2122 mL
5 mM 0.9537 mL 4.7685 mL 9.5370 mL 23.8424 mL
10 mM 0.4768 mL 2.3842 mL 4.7685 mL 11.9212 mL
15 mM 0.3179 mL 1.5895 mL 3.1790 mL 7.9475 mL
20 mM 0.2384 mL 1.1921 mL 2.3842 mL 5.9606 mL
25 mM 0.1907 mL 0.9537 mL 1.9074 mL 4.7685 mL
30 mM 0.1589 mL 0.7947 mL 1.5895 mL 3.9737 mL
40 mM 0.1192 mL 0.5961 mL 1.1921 mL 2.9803 mL
50 mM 0.0954 mL 0.4768 mL 0.9537 mL 2.3842 mL
60 mM 0.0795 mL 0.3974 mL 0.7947 mL 1.9869 mL
80 mM 0.0596 mL 0.2980 mL 0.5961 mL 1.4902 mL
100 mM 0.0477 mL 0.2384 mL 0.4768 mL 1.1921 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Muscarine chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muscarine2303-35-7(+)-MuscarinemAChRMuscarinic acetylcholine receptorIntracellular calciumNRMNeuronInhibitorinhibitorinhibit

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