Muvalaplin tetrahydrochloride (Synonyms: LY3473329 tetrahydrochloride)

Cat. No.: HY-46749 Purity: 99.55%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Muvalaplin tetrahydrochloride (LY3473329) is an orally active reagent of lipoprotein (a) (Lp (a)). At present, research on Muvalaplin tetrahydrochloride oral reagent is ongoing.

For research use only. We do not sell to patients.

Muvalaplin tetrahydrochloride Chemical Structure

CAS No. : 2565656-71-3

Size	Price	Stock	Quantity
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 660	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1980	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Muvalaplin tetrahydrochloride:

Muvalaplin Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Muvalaplin tetrahydrochloride (LY3473329) is an orally active reagent of lipoprotein (a) (Lp (a)). At present, research on Muvalaplin tetrahydrochloride oral reagent is ongoing^[1].

Molecular Weight

856.75

Formula

C₄₂H₅₈Cl₄N₄O₆

CAS No.

2565656-71-3

Appearance

Solid

Color

White to off-white

SMILES

OC([C@H]([C@H]1CCNC1)CC2=CC(CN(CC3=CC(C[C@@H]([C@H]4CCNC4)C(O)=O)=CC=C3)CC5=CC(C[C@@H]([C@H]6CCNC6)C(O)=O)=CC=C5)=CC=C2)=O.[H]Cl.[H]Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 133.33 mg/mL (155.62 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1672 mL	5.8360 mL	11.6720 mL
5 mM	0.2334 mL	1.1672 mL	2.3344 mL
10 mM	0.1167 mL	0.5836 mL	1.1672 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.55%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (257 KB) HNMR (296 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Bhatia HS, et al. Lipoprotein(a): Evidence for Role as a Causal Risk Factor in Cardiovascular Disease and Emerging Therapies. J Clin Med. 2022 Oct 13;11(20):6040. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.1672 mL	5.8360 mL	11.6720 mL	29.1800 mL
	5 mM	0.2334 mL	1.1672 mL	2.3344 mL	5.8360 mL
	10 mM	0.1167 mL	0.5836 mL	1.1672 mL	2.9180 mL
	15 mM	0.0778 mL	0.3891 mL	0.7781 mL	1.9453 mL
	20 mM	0.0584 mL	0.2918 mL	0.5836 mL	1.4590 mL
	25 mM	0.0467 mL	0.2334 mL	0.4669 mL	1.1672 mL
	30 mM	0.0389 mL	0.1945 mL	0.3891 mL	0.9727 mL
	40 mM	0.0292 mL	0.1459 mL	0.2918 mL	0.7295 mL
	50 mM	0.0233 mL	0.1167 mL	0.2334 mL	0.5836 mL
	60 mM	0.0195 mL	0.0973 mL	0.1945 mL	0.4863 mL
	80 mM	0.0146 mL	0.0730 mL	0.1459 mL	0.3648 mL
	100 mM	0.0117 mL	0.0584 mL	0.1167 mL	0.2918 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Muvalaplin tetrahydrochloride Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muvalaplin tetrahydrochloride2565656-71-3LY3473329 tetrahydrochlorideOthersLipoprotein(a) Lp(a)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks