MY33-3 hydrochloride

Name: MY33-3 hydrochloride
Brand: MedChemExpress
SKU: HY-123966A
Rating: 4.5 (1 reviews)

Cat. No.: HY-123966A Purity: 99.40%: FAQs
Data Sheet SDS COA Handling Instructions

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MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC₅₀ of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC₅₀ ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction.

For research use only. We do not sell to patients.

MY33-3 hydrochloride Chemical Structure

CAS No. : 2204280-42-0

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 760	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1220	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1950	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MY33-3 hydrochloride:

MY33-3 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

MY33-3 hydrochloride (1 μM; pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells^[1].
MY33-3 hydrochloride (0.1-10 μM; 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MY33-3 hydrochloride (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 hydrochloride reduces preference for the ethanol solution on day 3^[1].
MY33-3 hydrochloride (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

433.86

Formula

C₁₆H₁₄ClF₆NS₂

CAS No.

2204280-42-0

Appearance

Solid

Color

White to light yellow

SMILES

FC(F)(SC1=CC=C(CNCC2=CC=C(C=C2)SC(F)(F)F)C=C1)F.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (115.24 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3049 mL	11.5245 mL	23.0489 mL
5 mM	0.4610 mL	2.3049 mL	4.6098 mL
10 mM	0.2305 mL	1.1524 mL	2.3049 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.40%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (244 KB) HNMR (284 KB) LCMS (269 KB)

Handling Instructions (2659 KB)

References

[1]. Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. [Content Brief]

[2]. Fernández-Calle R, et, al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10(1):20259. [Content Brief]

[3]. Mao S, et, al. Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. J Mol Neurosci. 2022 Jan;72(1):48-55. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3049 mL	11.5245 mL	23.0489 mL	57.6223 mL
	5 mM	0.4610 mL	2.3049 mL	4.6098 mL	11.5245 mL
	10 mM	0.2305 mL	1.1524 mL	2.3049 mL	5.7622 mL
	15 mM	0.1537 mL	0.7683 mL	1.5366 mL	3.8415 mL
	20 mM	0.1152 mL	0.5762 mL	1.1524 mL	2.8811 mL
	25 mM	0.0922 mL	0.4610 mL	0.9220 mL	2.3049 mL
	30 mM	0.0768 mL	0.3841 mL	0.7683 mL	1.9207 mL
	40 mM	0.0576 mL	0.2881 mL	0.5762 mL	1.4406 mL
	50 mM	0.0461 mL	0.2305 mL	0.4610 mL	1.1524 mL
	60 mM	0.0384 mL	0.1921 mL	0.3841 mL	0.9604 mL
	80 mM	0.0288 mL	0.1441 mL	0.2881 mL	0.7203 mL
	100 mM	0.0230 mL	0.1152 mL	0.2305 mL	0.5762 mL