2. Apoptosis Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage MAPK/ERK Pathway
  3. Apoptosis Cytochrome P450 PARP JNK Bcl-2 Family Caspase
  4. Myrothecine A

Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC50s of 95, 70, 60, and 25 µM, respectively.

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Myrothecine A Chemical Structure

Myrothecine A Chemical Structure

CAS No. : 910292-40-9

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Myrothecine A Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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JNK1 JNK2 JNK3 JNK

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC50s of 95, 70, 60, and 25 µM, respectively[1][2][3].

IC50 & Target[3]

Caspase 3

 

Caspase-5

 

Caspase-8

 

Bax

 

Molecular Weight

546.61

Formula

C29H38O10
CAS No.
SMILES

CC1([C@@](OC(/C=C\CC[C@@]23C(C)=O)=O)([H])C[C@@]4([H])O5)[C@](CC[C@](O)6C)(COC(/C=C(CCO3)\[C@H]2O)=O)[C@H]5[C@]6([H])CC14O
Structure Classification
Initial Source

Myrothecium roridum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Myrothecine A Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myrothecine A910292-40-9ApoptosisCytochrome P450PARPJNKBcl-2 FamilyCaspaseCYPspoly ADP ribose polymerase c-Jun N-terminal kinaseInhibitorinhibitorinhibit

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