2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Platelet-activating Factor Receptor (PAFR) Histamine Receptor
  4. N-Acetyldesloratadine

N-Acetyldesloratadine  (Synonyms: SCH-37370)

Cat. No.: HY-116120 Purity: 99.93%
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N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM.

For research use only. We do not sell to patients.

N-Acetyldesloratadine Chemical Structure

N-Acetyldesloratadine Chemical Structure

CAS No. : 117796-52-8

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Based on 1 publication(s) in Google Scholar

N-Acetyldesloratadine Related Antibodies

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Description

N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
54.8 μM
Compound: 15, SCh-37370
Inhibition of eGFP-tagged human B0AT2 expressed in HEK293 cells measured within 10 mins by [3H]proline uptake assay
Inhibition of eGFP-tagged human B0AT2 expressed in HEK293 cells measured within 10 mins by [3H]proline uptake assay
[PMID: 25318072]
Molecular Weight

352.86

Formula

C21H21ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCN(CC\4)C(C)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.93%

SDS (393 KB)

COA (257 KB)

Handling Instructions (2659 KB)
References
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N-Acetyldesloratadine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetyldesloratadine117796-52-8SCH-37370SCH37370SCH 37370Platelet-activating Factor Receptor (PAFR)Histamine ReceptoraggregationplateletsInhibitorinhibitorinhibit

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