2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. N-Boc-cis-4-hydroxy-L-proline

N-Boc-cis-4-hydroxy-L-proline 

Cat. No.: HY-W002886 Purity: ≥97.0%
COA Handling Instructions

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N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2

For research use only. We do not sell to patients.

N-Boc-cis-4-hydroxy-L-proline Chemical Structure

N-Boc-cis-4-hydroxy-L-proline Chemical Structure

CAS No. : 87691-27-8

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Based on 1 publication(s) in Google Scholar

N-Boc-cis-4-hydroxy-L-proline Related Antibodies

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Description

N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Boc-cis-4-hydroxy-L-proline Related Antibodies
Molecular Weight

231.25

Formula

C10H17NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C)OC(N1[C@@H](C[C@@H](C1)O)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0% ee.: 100%

COA (251 KB) HNMR (126 KB) NP-HPLC (150 KB) OR (62 KB)

Handling Instructions (2659 KB)
References
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N-Boc-cis-4-hydroxy-L-proline Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Boc-cis-4-hydroxy-L-proline87691-27-8ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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