N-DBCO-N-bis(PEG2-C2-acid)

Name: N-DBCO-N-bis(PEG2-C2-acid)
Brand: MedChemExpress
SKU: HY-140543
Rating: 4.5 (1 reviews)

Cat. No.: HY-140543 Purity: 96.65%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-acid) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

N-DBCO-N-bis(PEG2-C2-acid) Chemical Structure

CAS No. : 2110449-00-6

Size	Price	Stock	Quantity
25 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 310	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. N-DBCO-N-bis(PEG2-C2-acid) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

624.68

Formula

C₃₃H₄₀N₂O₁₀

CAS No.

2110449-00-6

Appearance

Liquid (Density: 1.32 g/cm³)

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N(CCOCCOCCC(O)=O)CCOCCOCCC(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (200.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6008 mL	8.0041 mL	16.0082 mL
5 mM	0.3202 mL	1.6008 mL	3.2016 mL
10 mM	0.1601 mL	0.8004 mL	1.6008 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.65%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (249 KB) HNMR (306 KB) RP-HPLC (246 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6008 mL	8.0041 mL	16.0082 mL	40.0205 mL
	5 mM	0.3202 mL	1.6008 mL	3.2016 mL	8.0041 mL
	10 mM	0.1601 mL	0.8004 mL	1.6008 mL	4.0020 mL
	15 mM	0.1067 mL	0.5336 mL	1.0672 mL	2.6680 mL
	20 mM	0.0800 mL	0.4002 mL	0.8004 mL	2.0010 mL
	25 mM	0.0640 mL	0.3202 mL	0.6403 mL	1.6008 mL
	30 mM	0.0534 mL	0.2668 mL	0.5336 mL	1.3340 mL
	40 mM	0.0400 mL	0.2001 mL	0.4002 mL	1.0005 mL
	50 mM	0.0320 mL	0.1601 mL	0.3202 mL	0.8004 mL
	60 mM	0.0267 mL	0.1334 mL	0.2668 mL	0.6670 mL
	80 mM	0.0200 mL	0.1001 mL	0.2001 mL	0.5003 mL
	100 mM	0.0160 mL	0.0800 mL	0.1601 mL	0.4002 mL