2. PROTAC
  3. PROTAC Linkers
  4. N-DBCO-N-bis(PEG2-C2-NHS ester)

N-DBCO-N-bis(PEG2-C2-NHS ester) 

Cat. No.: HY-140585 Purity: ≥95.0%
COA Handling Instructions

Molarity Calculator

N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

N-DBCO-N-bis(PEG2-C2-NHS ester) Chemical Structure

N-DBCO-N-bis(PEG2-C2-NHS ester) Chemical Structure

CAS No. : 2128735-29-3

Size Price Stock Quantity
25 mg USD 265 In-stock
50 mg USD 410 In-stock
100 mg USD 700 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

N-DBCO-N-bis(PEG2-C2-NHS ester) Related Antibodies

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Description

N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-DBCO-N-bis(PEG2-C2-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-DBCO-N-bis(PEG2-C2-NHS ester) Related Antibodies
Molecular Weight

818.82

Formula

C41H46N4O14
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N(CCOCCOCCC(ON(C4=O)C(CC4)=O)=O)CCOCCOCCC(ON(C5=O)C(CC5)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (61.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2213 mL 6.1063 mL 12.2127 mL
5 mM 0.2443 mL 1.2213 mL 2.4425 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥96.0%

COA (251 KB) HNMR (139 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2213 mL 6.1063 mL 12.2127 mL 30.5317 mL
5 mM 0.2443 mL 1.2213 mL 2.4425 mL 6.1063 mL
10 mM 0.1221 mL 0.6106 mL 1.2213 mL 3.0532 mL
15 mM 0.0814 mL 0.4071 mL 0.8142 mL 2.0354 mL
20 mM 0.0611 mL 0.3053 mL 0.6106 mL 1.5266 mL
25 mM 0.0489 mL 0.2443 mL 0.4885 mL 1.2213 mL
30 mM 0.0407 mL 0.2035 mL 0.4071 mL 1.0177 mL
40 mM 0.0305 mL 0.1527 mL 0.3053 mL 0.7633 mL
50 mM 0.0244 mL 0.1221 mL 0.2443 mL 0.6106 mL
60 mM 0.0204 mL 0.1018 mL 0.2035 mL 0.5089 mL
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N-DBCO-N-bis(PEG2-C2-NHS ester) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-DBCO-N-bis(PEG2-C2-NHS ester)2128735-29-3PROTAC LinkersInhibitorinhibitorinhibit

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