2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. N-Deschlorobenzoyl indomethacin

N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the ​N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity.

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N-Deschlorobenzoyl indomethacin Chemical Structure

N-Deschlorobenzoyl indomethacin Chemical Structure

CAS No. : 2882-15-7

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N-Deschlorobenzoyl indomethacin Related Antibodies

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Description

N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the ​N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity[1].

Molecular Weight

219.24

Formula

C12H13NO3
CAS No.
Appearance

Solid

SMILES

CC(N1)=C(C2=C1C=CC(OC)=C2)CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
References
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N-Deschlorobenzoyl indomethacin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Deschlorobenzoyl indomethacin2882-15-7Drug MetaboliteAKR1C3 inhibitorInhibitorinhibitorinhibit

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