2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. N-Lactoyl-Phenylalanine

N-Lactoyl-Phenylalanine  (Synonyms: Lac-Phe)

Cat. No.: HY-150012 Purity: 99.82%
SDS COA Handling Instructions Technical Support

N-Lactoyl-Phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-Phenylalanine can reduce obesity and improve glucose tolerance.

For research use only. We do not sell to patients.

N-Lactoyl-Phenylalanine Chemical Structure

N-Lactoyl-Phenylalanine Chemical Structure

CAS No. : 183241-73-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
5 mg In-stock
10 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of N-Lactoyl-Phenylalanine:

N-Lactoyl-Phenylalanine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N-Lactoyl-Phenylalanine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N-Lactoyl-Phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-Phenylalanine can reduce obesity and improve glucose tolerance[1].

In Vivo

N-Lactoyl-Phenylalanine (50 mg/kg, i.p.,once a day for 10 days) specifically suppresses energy intake in obese mice without affecting energy expenditure pathways, and this effect is not observed in lean mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obese (DIO) mice model[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal (i.p.), once a day for 10 days
Result: Resulted in reduced cumulative food intake and reduced body weight compared with control mice. After 10 days, mice treated with N-Lactoyl-Phenylalanine also exhibited improved glucose homeostasis, and reduced adiposity without any changes in the weights of the other organs.
Molecular Weight

237.25

Formula

C12H15NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](O)C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 20.83 mg/mL (87.80 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2150 mL 21.0748 mL 42.1496 mL
5 mM 0.8430 mL 4.2150 mL 8.4299 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (42.15 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.82%

SDS (393 KB)

COA (253 KB) HNMR (247 KB) RP-HPLC (245 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.2150 mL 21.0748 mL 42.1496 mL 105.3741 mL
5 mM 0.8430 mL 4.2150 mL 8.4299 mL 21.0748 mL
10 mM 0.4215 mL 2.1075 mL 4.2150 mL 10.5374 mL
15 mM 0.2810 mL 1.4050 mL 2.8100 mL 7.0249 mL
20 mM 0.2107 mL 1.0537 mL 2.1075 mL 5.2687 mL
25 mM 0.1686 mL 0.8430 mL 1.6860 mL 4.2150 mL
30 mM 0.1405 mL 0.7025 mL 1.4050 mL 3.5125 mL
40 mM 0.1054 mL 0.5269 mL 1.0537 mL 2.6344 mL
50 mM 0.0843 mL 0.4215 mL 0.8430 mL 2.1075 mL
60 mM 0.0702 mL 0.3512 mL 0.7025 mL 1.7562 mL
80 mM 0.0527 mL 0.2634 mL 0.5269 mL 1.3172 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

N-Lactoyl-Phenylalanine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Lactoyl-Phenylalanine183241-73-8Lac-PheEndogenous Metaboliteblood-borne signalling metaboliteobesityexercise-inducibleInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
N-Lactoyl-Phenylalanine
Cat. No.:
HY-150012
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.