N-Nitrosomorpholine-d₈

Name: N-Nitrosomorpholine-d 8
Brand: MedChemExpress
SKU: HY-131123S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-131123S1 Purity: 99.74%: FAQs
Data Sheet SDS COA Handling Instructions

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N-Nitrosomorpholine-d₈ is deuterium labeled N-Nitrosomorpholine. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[1].

For research use only. We do not sell to patients.

N-Nitrosomorpholine-d<sub>8</sub> Chemical Structure

N-Nitrosomorpholine-d₈ Chemical Structure

CAS No. : 1219805-76-1

Size	Price	Stock	Quantity
5 mg	USD 225	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of N-Nitrosomorpholine-d₈:

N-Nitrosomorpholine Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

N-Nitrosomorpholine-d₈ is deuterium labeled N-Nitrosomorpholine. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

124.17

Formula

C₄D₈N₂O₂

CAS No.

1219805-76-1

Unlabeled CAS

59-89-2

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=NN1C([2H])([2H])C([2H])([2H])OC([2H])([2H])C1([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (805.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.0535 mL	40.2674 mL	80.5348 mL
5 mM	1.6107 mL	8.0535 mL	16.1070 mL
10 mM	0.8053 mL	4.0267 mL	8.0535 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.74%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (256 KB) HNMR (82 KB) RP-HPLC (384 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. K D Brunnemann, et al. N-Nitrosomorpholine and Other Volatile N-nitrosamines in Snuff Tobacco. Carcinogenesis. 1982;3(6):693-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.0535 mL	40.2674 mL	80.5348 mL	201.3369 mL
	5 mM	1.6107 mL	8.0535 mL	16.1070 mL	40.2674 mL
	10 mM	0.8053 mL	4.0267 mL	8.0535 mL	20.1337 mL
	15 mM	0.5369 mL	2.6845 mL	5.3690 mL	13.4225 mL
	20 mM	0.4027 mL	2.0134 mL	4.0267 mL	10.0668 mL
	25 mM	0.3221 mL	1.6107 mL	3.2214 mL	8.0535 mL
	30 mM	0.2684 mL	1.3422 mL	2.6845 mL	6.7112 mL
	40 mM	0.2013 mL	1.0067 mL	2.0134 mL	5.0334 mL
	50 mM	0.1611 mL	0.8053 mL	1.6107 mL	4.0267 mL
	60 mM	0.1342 mL	0.6711 mL	1.3422 mL	3.3556 mL
	80 mM	0.1007 mL	0.5033 mL	1.0067 mL	2.5167 mL
	100 mM	0.0805 mL	0.4027 mL	0.8053 mL	2.0134 mL