2. Apoptosis GPCR/G Protein
  3. Apoptosis Adenosine Receptor
  4. N6-Benzyladenosine

N6-Benzyladenosine  (Synonyms: Benzyladenosine)

Cat. No.: HY-N7844 Purity: 99.43%
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N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma-.

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N6-Benzyladenosine Chemical Structure

N6-Benzyladenosine Chemical Structure

CAS No. : 4294-16-0

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Based on 1 publication(s) in Google Scholar

N6-Benzyladenosine Related Antibodies

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Description

N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma[1]-[5].

In Vitro

N6-benzyladenosine suppresses the clonogenic activity and the growth of different neoplastic cells[2].
N6-benzyladenosine results cell morphology alteration and actin cytoskeleton disorganization in T24 cell[2].
N6-benzyladenosine (10 μM; 24 h) is a potent inductor of apoptosis, and belongs to apoptotic systems with distinct caspase-3 and caspase-9 activation[3].
N6-benzyladenosine (0-100 μM; 24 h) induces chromatin condensation, formation of apoptotic bodies, and cleavage of DNA to nucleosomal fragments in a dose-dependent manner[3].
N6-benzyladenosine acts as a selective anti-toxoplasma agent with binding affinity to T. gondii adenosine kinase (apparent Km =179.8 μM), over human adenosine kinase[4].
N6-benzyladenosine (0-50 μM) shows weak inhibition against adenosine kinase deficient (TgAKS3) strains of Toxoplasma gondii[4].
N6-benzyladenosine (compound 2) (0.3-20 μM) exerts anti-glioma activity by interfering with the mevalonate pathway and inhibiting FPPS (Farnesyl pyrophosphate synthase) [5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N6-Benzyladenosine Related Antibodies

Apoptosis Analysis[3]

Cell Line: HL-60
Concentration: 10 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis by increasing caspase-3 (DEVDase) as well as caspase-9 (LEHDase) activity, indicating an apoptotic systems with distinct caspase-3/9 activation.

Apoptosis Analysis[5]

Cell Line: U87MG human glioma cell line.
Concentration: 0.3, 0.6, 1.2, 2.5, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Inhibited glioma growth by interfering with the mevalonate pathway and inhibiting FPPS.
Molecular Weight

357.36

Formula

C17H19N5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1CO
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (349.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7983 mL 13.9915 mL 27.9830 mL
5 mM 0.5597 mL 2.7983 mL 5.5966 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7983 mL 13.9915 mL 27.9830 mL 69.9575 mL
5 mM 0.5597 mL 2.7983 mL 5.5966 mL 13.9915 mL
10 mM 0.2798 mL 1.3991 mL 2.7983 mL 6.9957 mL
15 mM 0.1866 mL 0.9328 mL 1.8655 mL 4.6638 mL
20 mM 0.1399 mL 0.6996 mL 1.3991 mL 3.4979 mL
25 mM 0.1119 mL 0.5597 mL 1.1193 mL 2.7983 mL
30 mM 0.0933 mL 0.4664 mL 0.9328 mL 2.3319 mL
40 mM 0.0700 mL 0.3498 mL 0.6996 mL 1.7489 mL
50 mM 0.0560 mL 0.2798 mL 0.5597 mL 1.3991 mL
60 mM 0.0466 mL 0.2332 mL 0.4664 mL 1.1660 mL
80 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8745 mL
100 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6996 mL
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N6-Benzyladenosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N6-Benzyladenosine4294-16-0BenzyladenosineApoptosisAdenosine ReceptorP1 receptorFPPSFarnesyl pyrophosphate synthasemass spectrometryanti-tumorneoplastic cellscaspase-3/9anti-toxoplasmaadenosine kinaseTgAKS3gliomabenzyladenosine hydroxylatedcytokinin activityInhibitorinhibitorinhibit

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