NADP sodium hydrate

Name: NADP sodium hydrate
Brand: MedChemExpress
SKU: HY-113325A
Rating: 5.0 (6 reviews)

Cat. No.: HY-113325A Purity: 99.03%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.

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NADP sodium hydrate Chemical Structure

CAS No. : 698999-85-8

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100 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
1 g	USD 195	In-stock	Estimated Time of Arrival: December 31
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Based on 6 publication(s) in Google Scholar

Other Forms of NADP sodium hydrate:

NADP sodium salt In-stock
NADP Get quote
NADP disodium salt Get quote

6 Publications Citing Use of MCE NADP sodium hydrate

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

NADP sodium hydrate can impair folate metabolism and nucleotide biosynthesis in HCT116 cells at high concentrations, leading to the cessation of proliferation and prioritizing cell survival^[1].
NADP sodium hydrate forms NAADP through IL-8-driven CD38 to mobilize Ca²⁺ and influence cell migration^[2].
NADP sodium hydrate de novo synthesis mediated by NADK upregulation provides power for anabolic reaction and antioxidant system to promote breast cancer metastasis^[3].
NADP sodium hydrate is upregulated in ROS generation mediated by hyperglycemia and IDPc induction, thereby protecting renal cells from oxidative stress^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

783.40

Formula

C₂₁H₂₉N₇NaO₁₈P₃

CAS No.

698999-85-8

Appearance

Solid

Color

White to off-white

SMILES

O=P(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O1)([O-])OP(OC[C@H]3O[C@@H](N4C5=NC=NC(N)=C5N=C4)[C@H](OP(O)(O)=O)[C@@H]3O)(O[Na])=O.O.[x]

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (159.56 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2765 mL	6.3824 mL	12.7649 mL
5 mM	0.2553 mL	1.2765 mL	2.5530 mL
10 mM	0.1276 mL	0.6382 mL	1.2765 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.03%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (259 KB) HNMR (281 KB) CNMR (303 KB) RP-HPLC (278 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Chen L, et al. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019 Mar;1:404-415. Epub 2019 Mar 11. PMID: 31058257; PMCID: PMC6489125. [Content Brief]

[2]. Nam TS, et al. Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration. FASEB J. 2020 Sep;34(9):12565-12576. [Content Brief]

[3]. Ilter D, et al. NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023 May;61:102627. [Content Brief]

[4]. Lee SH, et al. Upregulation of cytosolic NADP+-dependent isocitrate dehydrogenase by hyperglycemia protects renal cells against oxidative stress. Mol Cells. 2010 Feb 28;29(2):203-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.2765 mL	6.3824 mL	12.7649 mL	31.9122 mL
	5 mM	0.2553 mL	1.2765 mL	2.5530 mL	6.3824 mL
	10 mM	0.1276 mL	0.6382 mL	1.2765 mL	3.1912 mL
	15 mM	0.0851 mL	0.4255 mL	0.8510 mL	2.1275 mL
	20 mM	0.0638 mL	0.3191 mL	0.6382 mL	1.5956 mL
	25 mM	0.0511 mL	0.2553 mL	0.5106 mL	1.2765 mL
	30 mM	0.0425 mL	0.2127 mL	0.4255 mL	1.0637 mL
	40 mM	0.0319 mL	0.1596 mL	0.3191 mL	0.7978 mL
	50 mM	0.0255 mL	0.1276 mL	0.2553 mL	0.6382 mL
	60 mM	0.0213 mL	0.1064 mL	0.2127 mL	0.5319 mL
	80 mM	0.0160 mL	0.0798 mL	0.1596 mL	0.3989 mL
	100 mM	0.0128 mL	0.0638 mL	0.1276 mL	0.3191 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.