2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. NADP sodium salt

NADP sodium salt  (Synonyms: Sodium NADP)

Cat. No.: HY-F0002 Purity: 99.43%
SDS COA Handling Instructions

Molarity Calculator

NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.

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NADP sodium salt Chemical Structure

NADP sodium salt Chemical Structure

CAS No. : 1184-16-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 73 In-stock
Solution
10 mM * 1 mL in Water USD 73 In-stock
Solid
100 mg USD 66 In-stock
500 mg USD 192 In-stock
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Based on 6 publication(s) in Google Scholar

Other Forms of NADP sodium salt:

NADP sodium salt Related Antibodies

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  • Purity & Documentation

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Description

NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4].
IC50 & Target

Human Endogenous Metabolite

 

In Vitro

NADP sodium salt can impair folate metabolism and nucleotide biosynthesis in HCT116 cells at high concentrations, leading to the cessation of proliferation and prioritizing cell survival[1].
NADP sodium salt forms NAADP through IL-8-driven CD38 to mobilize Ca2+ and influence cell migration[2].
NADP sodium salt de novo synthesis mediated by NADK upregulation provides power for anabolic reaction and antioxidant system to promote breast cancer metastasis[3].
NADP sodium salt is upregulated in ROS generation mediated by hyperglycemia and IDPc induction, thereby protecting renal cells from oxidative stress[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NADP sodium salt Related Antibodies
Molecular Weight

765.39

Formula

C21H27N7NaO17P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O[C@@H]1COP([O-])(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)([O-])=O)=O.[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (130.65 mM; Need ultrasonic)

DMSO : 3.57 mg/mL (4.66 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3065 mL 6.5326 mL 13.0652 mL
5 mM 0.2613 mL 1.3065 mL 2.6130 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (130.65 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.43%

SDS (393 KB)

COA (262 KB) HNMR (324 KB) RP-HPLC (245 KB) MS (180 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.3065 mL 6.5326 mL 13.0652 mL 32.6631 mL
H2O 5 mM 0.2613 mL 1.3065 mL 2.6130 mL 6.5326 mL
10 mM 0.1307 mL 0.6533 mL 1.3065 mL 3.2663 mL
15 mM 0.0871 mL 0.4355 mL 0.8710 mL 2.1775 mL
20 mM 0.0653 mL 0.3266 mL 0.6533 mL 1.6332 mL
25 mM 0.0523 mL 0.2613 mL 0.5226 mL 1.3065 mL
30 mM 0.0436 mL 0.2178 mL 0.4355 mL 1.0888 mL
40 mM 0.0327 mL 0.1633 mL 0.3266 mL 0.8166 mL
50 mM 0.0261 mL 0.1307 mL 0.2613 mL 0.6533 mL
60 mM 0.0218 mL 0.1089 mL 0.2178 mL 0.5444 mL
80 mM 0.0163 mL 0.0817 mL 0.1633 mL 0.4083 mL
100 mM 0.0131 mL 0.0653 mL 0.1307 mL 0.3266 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NADP sodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NADP1184-16-3Sodium NADPEndogenous Metaboliteelectron transferbiological metabolismLAK cellbreast cancerInhibitorinhibitorinhibit

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