2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. NADP disodium salt

NADP disodium salt  (Synonyms: Disodium NADP)

Cat. No.: HY-F0002A Purity: 99.41%
SDS COA Handling Instructions

Molarity Calculator

NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.

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NADP disodium salt Chemical Structure

NADP disodium salt Chemical Structure

CAS No. : 24292-60-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 73 In-stock
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10 mM * 1 mL in Water USD 73 In-stock
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Based on 6 publication(s) in Google Scholar

Other Forms of NADP disodium salt:

NADP disodium salt Related Antibodies

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Description

NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4].
IC50 & Target

Human Endogenous Metabolite

 

In Vitro

NADP disodium salt can impair folate metabolism and nucleotide biosynthesis in HCT116 cells at high concentrations, leading to the cessation of proliferation and prioritizing cell survival[1].
NADP disodium salt forms NAADP through IL-8-driven CD38 to mobilize Ca2+ and influence cell migration[2].
NADP disodium salt de novo synthesis mediated by NADK upregulation provides power for anabolic reaction and antioxidant system to promote breast cancer metastasis[3].
NADP disodium salt is upregulated in ROS generation mediated by hyperglycemia and IDPc induction, thereby protecting renal cells from oxidative stress[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NADP disodium salt Related Antibodies
Molecular Weight

789.39

Formula

C21H28N7O17P3.2Na
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O[C@@H]1COP([O-])(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)(O)=O)=O.[2Na]
Structure Classification
Initial Source

Widespread
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (316.70 mM; Need ultrasonic)

DMSO : 3.33 mg/mL (4.22 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2668 mL 6.3340 mL 12.6680 mL
5 mM 0.2534 mL 1.2668 mL 2.5336 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (126.68 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.41%

SDS (393 KB)

COA (262 KB) HNMR (298 KB) RP-HPLC (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.2668 mL 6.3340 mL 12.6680 mL 31.6700 mL
H2O 5 mM 0.2534 mL 1.2668 mL 2.5336 mL 6.3340 mL
10 mM 0.1267 mL 0.6334 mL 1.2668 mL 3.1670 mL
15 mM 0.0845 mL 0.4223 mL 0.8445 mL 2.1113 mL
20 mM 0.0633 mL 0.3167 mL 0.6334 mL 1.5835 mL
25 mM 0.0507 mL 0.2534 mL 0.5067 mL 1.2668 mL
30 mM 0.0422 mL 0.2111 mL 0.4223 mL 1.0557 mL
40 mM 0.0317 mL 0.1584 mL 0.3167 mL 0.7918 mL
50 mM 0.0253 mL 0.1267 mL 0.2534 mL 0.6334 mL
60 mM 0.0211 mL 0.1056 mL 0.2111 mL 0.5278 mL
80 mM 0.0158 mL 0.0792 mL 0.1584 mL 0.3959 mL
100 mM 0.0127 mL 0.0633 mL 0.1267 mL 0.3167 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NADP disodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NADP disodium24292-60-2Disodium NADPEndogenous Metaboliteelectron transferbiological metabolismLAK cellbreast cancerInhibitorinhibitorinhibit

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