2. PROTAC Cell Cycle/DNA Damage
  3. Molecular Glues CDK
  4. NCT02

NCT02 is a cyclin K molecular glue. NCT02 induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. NCT02 has the potential for the research of metastatic colorectal cancer (CRC).

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NCT02 Chemical Structure

NCT02 Chemical Structure

CAS No. : 790245-61-3

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Based on 1 publication(s) in Google Scholar

NCT02 Related Antibodies

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Description

NCT02 is a cyclin K molecular glue. NCT02 induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. NCT02 has the potential for the research of metastatic colorectal cancer (CRC)[1].

Molecular Weight

312.39

Formula

C17H16N2O2S
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(NC1=NC=C(C)S1)CC2=COC3=CC4=C(CCC4)C=C32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (160.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2011 mL 16.0054 mL 32.0109 mL
5 mM 0.6402 mL 3.2011 mL 6.4022 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2011 mL 16.0054 mL 32.0109 mL 80.0271 mL
5 mM 0.6402 mL 3.2011 mL 6.4022 mL 16.0054 mL
10 mM 0.3201 mL 1.6005 mL 3.2011 mL 8.0027 mL
15 mM 0.2134 mL 1.0670 mL 2.1341 mL 5.3351 mL
20 mM 0.1601 mL 0.8003 mL 1.6005 mL 4.0014 mL
25 mM 0.1280 mL 0.6402 mL 1.2804 mL 3.2011 mL
30 mM 0.1067 mL 0.5335 mL 1.0670 mL 2.6676 mL
40 mM 0.0800 mL 0.4001 mL 0.8003 mL 2.0007 mL
50 mM 0.0640 mL 0.3201 mL 0.6402 mL 1.6005 mL
60 mM 0.0534 mL 0.2668 mL 0.5335 mL 1.3338 mL
80 mM 0.0400 mL 0.2001 mL 0.4001 mL 1.0003 mL
100 mM 0.0320 mL 0.1601 mL 0.3201 mL 0.8003 mL
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NCT02 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCT02790245-61-3NCT 02NCT-02Molecular GluesCDKCyclin dependent kinasecyclin Kproteasomal degradationCCNKubiquitinationCDK12metastatic colorectal cancerInhibitorinhibitorinhibit

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