2. Anti-infection
  3. Antibiotic Bacterial
  4. Neamine tetrahydrochloride

Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities.

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Neamine tetrahydrochloride Chemical Structure

Neamine tetrahydrochloride Chemical Structure

CAS No. : 15446-43-2

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Neamine tetrahydrochloride Related Antibodies

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Description

Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities[1][2].

IC50 & Target

Aminoglycoside

 

In Vitro

Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM[1].
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neamine tetrahydrochloride Related Antibodies

Cell Proliferation Assay[1]

Cell Line: AsPC-1 cells
Concentration: 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM
Incubation Time: 48 hours
Result: Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.
In Vivo

Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells[1]
Dosage: 30 mg/kg, 60 mg/kg
Administration: Subcutaneous injection; daily; for 14 days
Result: Had anti-tumor effects on AsPC-1 xenograft models.
Molecular Weight

468.20

Formula

C12H30Cl4N4O6
CAS No.
SMILES

O[C@H]([C@H]([C@@H](C[C@@H]1N)N)O)[C@@H]1O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2N)O)O)CN.Cl.Cl.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Neamine tetrahydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neamine tetrahydrochloride15446-43-2AntibioticBacterialAngiogeninaminoglycosideantibioticantibacterialantitumorNeomycinKi-67CD31anti-angiogenesisneuroprotectiveInhibitorinhibitorinhibit

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Neamine tetrahydrochloride
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