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  4. Necrostatin-1 (inactive control)

Necrostatin-1 (inactive control)  (Synonyms: Nec-1 (inactive control))

Cat. No.: HY-121954 Purity: 98.60%
COA Handling Instructions

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Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor.

For research use only. We do not sell to patients.

Necrostatin-1 (inactive control) Chemical Structure

Necrostatin-1 (inactive control) Chemical Structure

CAS No. : 64419-92-7

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1 mg USD 79 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor[1].

Molecular Weight

245.30

Formula

C12H11N3OS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)C(CC2=CNC3=CC=CC=C32)NC1=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 20 mg/mL (81.53 mM; Need ultrasonic and warming)

DMSO : 14 mg/mL (57.07 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0766 mL 20.3832 mL 40.7664 mL
5 mM 0.8153 mL 4.0766 mL 8.1533 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.60%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 4.0766 mL 20.3832 mL 40.7664 mL 101.9160 mL
5 mM 0.8153 mL 4.0766 mL 8.1533 mL 20.3832 mL
10 mM 0.4077 mL 2.0383 mL 4.0766 mL 10.1916 mL
15 mM 0.2718 mL 1.3589 mL 2.7178 mL 6.7944 mL
20 mM 0.2038 mL 1.0192 mL 2.0383 mL 5.0958 mL
25 mM 0.1631 mL 0.8153 mL 1.6307 mL 4.0766 mL
30 mM 0.1359 mL 0.6794 mL 1.3589 mL 3.3972 mL
40 mM 0.1019 mL 0.5096 mL 1.0192 mL 2.5479 mL
50 mM 0.0815 mL 0.4077 mL 0.8153 mL 2.0383 mL
DMF 60 mM 0.0679 mL 0.3397 mL 0.6794 mL 1.6986 mL
80 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2740 mL
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Necrostatin-1 (inactive control) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Necrostatin-1 (inactive control)64419-92-7Nec-1 (inactive control)OthersInhibitorinhibitorinhibit

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