Nek2-IN-6

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Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor.

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Nek2-IN-6 Chemical Structure

CAS No. : 2410376-96-2

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NEK1 NEK2 NEK6 NEK7

Biological Activity
Purity & Documentation
References
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Description

Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor^[1].

IC₅₀ & Target

NEK2

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	10.44 μM Compound: 28e	Antitumor activity against human Bel-7402 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antitumor activity against human Bel-7402 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 32992252]
HCT-116	IC₅₀	0.48 μM Compound: 28e	Antitumor activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antitumor activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 32992252]
Hep 3B2	IC₅₀	1.25 μM Compound: 28e	Antitumor activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antitumor activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 32992252]
MGC-803	IC₅₀	0.038 μM Compound: 28e	Antitumor activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antitumor activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 32992252]

In Vitro

Nek2-IN-6 (Compound 28e) (0-30 μM; 72 h) inhibits tumor cells proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MGC-803, Hep-3B, BEL-7402, HCT-116
Concentration:	0-30 μM
Incubation Time:	72 h
Result:	Inhibited cell proliferation with IC₅₀s of 0.038, 1.25, 10.44 and 0.48 μM against MGC-803, Hep-3B, BEL-7402 and HCT-116 cells, respectively.

Molecular Weight

666.71

Formula

C₃₃H₃₃F₃N₆O₄S

CAS No.

2410376-96-2

SMILES

CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(C3=CN=C4C=C(C=CN34)C5=CN(N=C5)CC6CN(C6)C(OC(C)(C)C)=O)=C2)C(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang H, et al. Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo[1,2-a] pyridine derivatives as Nek2 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115775. [Content Brief]

Nek2-IN-6 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nek2-IN-62410376-96-2NEKsNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed KinasesNek2NIMAnever in mitosis related kinase 2MGC-803Hep-3BBEL-7402HCT-116Inhibitorinhibitorinhibit

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