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Nelutroctiv  (Synonyms: CK-136)

Cat. No.: HY-147292 Purity: 99.38%
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Nelutroctiv (CK-136) is a potent cardiac troponin activator.

For research use only. We do not sell to patients.

Nelutroctiv Chemical Structure

Nelutroctiv Chemical Structure

CAS No. : 2299177-09-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 813 In-stock
Solution
10 mM * 1 mL in DMSO USD 813 In-stock
Solid
5 mg USD 680 In-stock
10 mg USD 1100 In-stock
25 mg USD 2250 In-stock
50 mg USD 3500 In-stock
100 mg USD 5600 In-stock
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Nelutroctiv (CK-136) is a potent cardiac troponin activator[1].

Molecular Weight

543.51

Formula

C24H22F5N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN=CC(S(C)(=O)=O)=C1)N2[C@@]3([H])[C@](C[C@@H]2C(N[C@H](C4CC4)C5=C(C=C(C(F)=C5)C(F)(F)F)F)=O)([H])C3
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (183.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8399 mL 9.1995 mL 18.3989 mL
5 mM 0.3680 mL 1.8399 mL 3.6798 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8399 mL 9.1995 mL 18.3989 mL 45.9973 mL
5 mM 0.3680 mL 1.8399 mL 3.6798 mL 9.1995 mL
10 mM 0.1840 mL 0.9199 mL 1.8399 mL 4.5997 mL
15 mM 0.1227 mL 0.6133 mL 1.2266 mL 3.0665 mL
20 mM 0.0920 mL 0.4600 mL 0.9199 mL 2.2999 mL
25 mM 0.0736 mL 0.3680 mL 0.7360 mL 1.8399 mL
30 mM 0.0613 mL 0.3066 mL 0.6133 mL 1.5332 mL
40 mM 0.0460 mL 0.2300 mL 0.4600 mL 1.1499 mL
50 mM 0.0368 mL 0.1840 mL 0.3680 mL 0.9199 mL
60 mM 0.0307 mL 0.1533 mL 0.3066 mL 0.7666 mL
80 mM 0.0230 mL 0.1150 mL 0.2300 mL 0.5750 mL
100 mM 0.0184 mL 0.0920 mL 0.1840 mL 0.4600 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nelutroctiv2299177-09-4CK-136CK136CK 136Otherscardiac troponincardiovascularheartInhibitorinhibitorinhibit

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