2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. NESS 0327

NESS 0327 is a cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.

For research use only. We do not sell to patients.

NESS 0327 Chemical Structure

NESS 0327 Chemical Structure

CAS No. : 494844-07-4

Size Price Stock Quantity
5 mg USD 135 In-stock
10 mg USD 230 In-stock
25 mg USD 520 In-stock
50 mg USD 890 In-stock
100 mg USD 1450 Get quote
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

NESS 0327 Related Antibodies

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CB1 CB2

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  • Purity & Documentation

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Description

NESS 0327 is a cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor[1].

Molecular Weight

489.82

Formula

C24H23Cl3N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C3=C1CCCC4=CC(Cl)=CC=C43)NN5CCCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.7 mg/mL (19.80 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0416 mL 10.2078 mL 20.4157 mL
5 mM 0.4083 mL 2.0416 mL 4.0831 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0416 mL 10.2078 mL 20.4157 mL 51.0392 mL
5 mM 0.4083 mL 2.0416 mL 4.0831 mL 10.2078 mL
10 mM 0.2042 mL 1.0208 mL 2.0416 mL 5.1039 mL
15 mM 0.1361 mL 0.6805 mL 1.3610 mL 3.4026 mL
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NESS 0327 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NESS 0327494844-07-4NESS0327NESS-0327Cannabinoid ReceptorCB1 cannabinoid receptorselectiveInhibitorinhibitorinhibit

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NESS 0327
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HY-117139
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