2. Immunology/Inflammation Neuronal Signaling
  3. NO Synthase COX Cholinesterase (ChE) Amyloid-β
  4. Neuroprotective agent 5

Neuroprotective agent 5 (compound 28) is a brain permeabilizing agent with anti-neuritis, anti-oxidative damage and neuroprotective effects. Neuroprotective agent 5 exhibits a potent NO inhibitory effect (EC50=0.49 μM), inhibits the release of proinflammatory factors PGE2 and TNF-α, downregulates the expression of iNOS and COX-2 proteins, and promotes the polarization of BV-2 cells from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype. In addition, Neuroprotective agent 5 can also inhibit acetylcholinesterase (AChE) activity and Aβ42 aggregation in a dose-dependent manner. Neuroprotective agent 5 can be used for the study of Alzheimer's disease.

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Neuroprotective agent 5 Chemical Structure

Neuroprotective agent 5 Chemical Structure

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Neuroprotective agent 5 Related Antibodies

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Description

Neuroprotective agent 5 (compound 28) is a brain permeabilizing agent with anti-neuritis, anti-oxidative damage and neuroprotective effects. Neuroprotective agent 5 exhibits a potent NO inhibitory effect (EC50=0.49 μM), inhibits the release of proinflammatory factors PGE2 and TNF-α, downregulates the expression of iNOS and COX-2 proteins, and promotes the polarization of BV-2 cells from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype. In addition, Neuroprotective agent 5 can also inhibit acetylcholinesterase (AChE) activity and Aβ42 aggregation in a dose-dependent manner. Neuroprotective agent 5 can be used for the study of Alzheimer's disease[1].

IC50 & Target

血脑
Molecular Weight

291.28

Formula

C14H14FN3O3
SMILES

FCCO/N=C(CN1C=CN=C1)/C2=CC(OCO3)=C3C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Neuroprotective agent 5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuroprotective agent 5Neuroprotective agent5Neuroprotective agent-5NO SynthaseCOXCholinesterase (ChE)Amyloid-βNitric oxide synthasesNOSCyclooxygenaseβ-amyloid peptideAβAbetaAlzheimer's diseaseoxidative damageneuroprotectionBV-2 cellsproinflammatory factorsInhibitorinhibitorinhibit

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