2. NF-κB MAPK/ERK Pathway
  3. NF-κB p38 MAPK
  4. NF-κB/MAPK-IN-2

NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis.

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NF-κB/MAPK-IN-2 Chemical Structure

NF-κB/MAPK-IN-2 Chemical Structure

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NF-κB/MAPK-IN-2 Related Antibodies

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis[1].

Molecular Weight

827.06

Formula

C49H66N2O9
SMILES

C[C@]1(C2=C(C[C@]3([C@@]1([H])CC[C@@]4([C@]3([H])CC=C5[C@]4(CC[C@@]6([C@@]5([H])CC(C)(CC6)C)C(OCC7=CC=CC=C7)=O)C)C)C)C(C(OCC)=O)=NO2)COC(CCC(N8CCOCC8)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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NF-κB/MAPK-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB/MAPK-IN-2NF-κBp38 MAPKNuclear factor-κBNuclear factor-kappaBNF-αIL-6RAW264.7 cellsp-p65sepsis-p65p-IκBp-p38p-JNKp-ERKInhibitorinhibitorinhibit

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