2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. NGD9002 free base

NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension.

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NGD9002 free base Chemical Structure

NGD9002 free base Chemical Structure

CAS No. : 666256-06-0

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NGD9002 free base Related Antibodies

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Description

NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension[1].

Molecular Weight

357.49

Formula

C20H31N5O
CAS No.
SMILES

CC1=C(N=C(C(NC(CC)CC)=N1)OC)C2=CC=C(N=C2NC)C(C)C
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NGD9002 free base Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NGD9002666256-06-0NGD 9002NGD-9002Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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